Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis.
atherosclerosis
cell biology
endothelial cells
human
immunology
inflammation
kallikreins
mechanobiology
mouse
shear stress
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
11 01 2022
11 01 2022
Historique:
received:
28
07
2021
accepted:
08
01
2022
pubmed:
12
1
2022
medline:
25
2
2022
entrez:
11
1
2022
Statut:
epublish
Résumé
Atherosclerosis preferentially occurs in arterial regions exposed to disturbed blood flow (
Identifiants
pubmed: 35014606
doi: 10.7554/eLife.72579
pii: 72579
pmc: PMC8806187
doi:
pii:
Substances chimiques
Kallikreins
EC 3.4.21.-
Klk10 protein, mouse
EC 3.4.21.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL142975
Pays : United States
Organisme : NHLBI NIH HHS
ID : F31 HL145974
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008602
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008169
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL139757
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL119798
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL104165
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL158571
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148096
Pays : United States
Organisme : Cancer Research UK
ID : C24523/A25192
Pays : United Kingdom
Déclaration de conflit d'intérêts
DW, MM, RL, AA, SK, DK, JZ, IT, NV, KB, LZ, ET, PB, JP, LM, KM, MH, ZD No competing interests declared, HL, YA is affiliated with Celltrion. The author has no financial interests to declare, ED has consulted for Abbott diagnostics and Imaware Disgnostics. The author has no other competing interest to declare, HJ is the founder of FloKines Pharma
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