Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection.
SARS-CoV2
cardiovascular
hamster
infectious disease
microbiology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
11 01 2022
11 01 2022
Historique:
received:
01
09
2021
accepted:
07
01
2022
pubmed:
12
1
2022
medline:
2
2
2022
entrez:
11
1
2022
Statut:
epublish
Résumé
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extrapulmonary pathologies associated with SARS-CoV-2 infection and post-COVID sequelae remain to be understood. Here, we show, using a hamster model, that the early phase of SARS-CoV-2 infection leads to an acute inflammatory response and lung pathologies, while the late phase of infection causes cardiovascular complications (CVCs) characterized by ventricular wall thickening associated with increased ventricular mass/body mass ratio and interstitial coronary fibrosis. Molecular profiling further substantiated our findings of CVC as SARS-CoV-2-infected hamsters showed elevated levels of serum cardiac troponin I, cholesterol, low-density lipoprotein, and long-chain fatty acid triglycerides. Serum metabolomics profiling of SARS-CoV-2-infected hamsters identified N-acetylneuraminate, a functional metabolite found to be associated with CVC, as a metabolic marker was found to be common between SARS-CoV-2-infected hamsters and COVID-19 patients. Together, we propose hamsters as a suitable animal model to study post-COVID sequelae associated with CVC, which could be extended to therapeutic interventions.
Identifiants
pubmed: 35014610
doi: 10.7554/eLife.73522
pii: 73522
pmc: PMC8794466
doi:
pii:
Substances chimiques
Lipoproteins, LDL
0
Triglycerides
0
Troponin I
0
Cholesterol
97C5T2UQ7J
Banques de données
Dryad
['10.5061/dryad.vhhmgqnvt']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Rizvi et al.
Déclaration de conflit d'intérêts
ZR, RD, SS, AB, JD, YK, TS, SG, SA, MT, DR, AY, GM, AP, SS, SA, AA No competing interests declared
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