Response to comment on 'SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lung'.
COVID-19
SARS-CoV-2
bronchoalvelolar
coagulation
computational biology
fibrinolysis
human
systems biology
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
11 01 2022
11 01 2022
Historique:
received:
25
10
2021
accepted:
24
11
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
15
1
2022
Statut:
epublish
Résumé
Early in the SARS-CoV-2 pandemic, we compared transcriptome data from hospitalized COVID-19 patients and control patients without COVID-19. We found changes in procoagulant and fibrinolytic gene expression in the lungs of COVID-19 patients (Mast et al., 2021). These findings have been challenged based on issues with the samples (Fitzgerald and Jamieson, 2022). We have revisited our previous analyses in the light of this challenge and find that these new analyses support our original conclusions.
Identifiants
pubmed: 35014952
doi: 10.7554/eLife.74951
pii: 74951
pmc: PMC8752086
doi:
pii:
Substances chimiques
Anticoagulants
0
Types de publication
Journal Article
Comment
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL126974
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL140025
Pays : United States
Commentaires et corrections
Type : CommentOn
Informations de copyright
© 2022, Mast et al.
Déclaration de conflit d'intérêts
AM receives research funding from Novo Nordisk and has received honoraria for serving on Novo Nordisk advisory boards, AW Receives research funding from Takeda and Bristol Myers Squibb, DG Receives research funding from Bayer and has received honoraria for serving on Anthos, Bristol-Myers Squibb, Ionis and Janssen advisory boards, MG, CA, JM, PJ, BA, DJ No competing interests declared
Références
RNA. 2020 Aug;26(8):903-909
pubmed: 32284352
Blood. 2020 Sep 10;136(11):1330-1341
pubmed: 32678428
J Clin Invest. 2020 Nov 2;130(11):6151-6157
pubmed: 32759504
PLoS One. 2020 Nov 11;15(11):e0241825
pubmed: 33175863
Blood. 2021 Jul 29;138(4):344-349
pubmed: 34075401
Nat Biotechnol. 2014 Sep;32(9):896-902
pubmed: 25150836
Elife. 2022 Jan 11;11:
pubmed: 35014954
Elife. 2021 Mar 08;10:
pubmed: 33683204