Redox-dependent internalization of the purinergic P2Y
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
11 01 2022
11 01 2022
Historique:
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
1
4
2022
Statut:
ppublish
Résumé
After ligand stimulation, many G protein–coupled receptors (GPCRs) undergo β-arrestin–dependent desensitization, during which they are internalized and either degraded or recycled to the plasma membrane. Some GPCRs are not subject to this type of desensitization because they lack the residues required to interact with β-arrestins. We identified a mechanism of redox-dependent alternative internalization (REDAI) that promotes the internalization and degradation of the purinergic P2Y
Identifiants
pubmed: 35015570
doi: 10.1126/scisignal.abj0644
doi:
Substances chimiques
Receptors, Purinergic P2
0
beta-Arrestins
0
purinoceptor P2Y6
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM