Lysosomal potassium channels.

Calcium / metabolism Humans Intracellular Membranes / metabolism Ion Channels / metabolism Ions / metabolism Lysosomes / metabolism Potassium / metabolism Potassium Channels / metabolism
BK channel Lysosome TMEM175 TRPML1

Journal

Cell calcium
ISSN: 1532-1991
Titre abrégé: Cell Calcium
Pays: Netherlands
ID NLM: 8006226

Informations de publication

Date de publication:
03 2022
Historique:
received: 18 11 2021
revised: 04 01 2022
accepted: 05 01 2022
pubmed: 12 1 2022
medline: 3 5 2022
entrez: 11 1 2022
Statut: ppublish

Résumé

The lysosome is an important membrane-bound acidic organelle that is regarded as the degradative center as well as multifunctional signaling hub. It digests unwanted macromolecules, damaged organelles, microbes, and other materials derived from endocytosis, autophagy, and phagocytosis. To function properly, the ionic homeostasis and membrane potential of the lysosome are strictly regulated by transporters and ion channels. As the most abundant cation inside the cell, potassium ions (K

Identifiants

DOI: 10.1016/j.ceca.2022.102536 PMID: 35016151
pubmed: 35016151
pii: S0143-4160(22)00011-2
doi: 10.1016/j.ceca.2022.102536
pii:
doi:

Substances chimiques

Ion Channels 0
Ions 0
Potassium Channels 0
Potassium RWP5GA015D
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

102536

Informations de copyright

Copyright © 2022. Published by Elsevier Ltd.

Auteurs

Yi Wu (Y)

Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine and Health Sciences, 279 Zhouzhu Rd, Shanghai 201318, China; School of Pharmacy, Shanghai University of Medicine and Health Sciences, 279 Zhouzhu Rd, Shanghai 201318, China.

Mengnan Xu (M)

Department of Physiology and Biophysics, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova NS B3H 4R2, Canada.

Pingping Wang (P)

Department of Physiology and Biophysics, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova NS B3H 4R2, Canada.

Alia Kazim Rizvi Syeda (AKR)

Department of Physiology and Biophysics, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova NS B3H 4R2, Canada.

Peng Huang (P)

Collaborative Innovation Center for Biomedicine, Shanghai University of Medicine and Health Sciences, 279 Zhouzhu Rd, Shanghai 201318, China; School of Clinical Medicine, Shanghai University of Medicine and Health Sciences, 279 Zhouzhu Rd, Shanghai 201318, China. Electronic address: huangp_15@sumhs.edu.cn.

Xian-Ping Dong (XP)

Department of Physiology and Biophysics, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova NS B3H 4R2, Canada. Electronic address: xpdong@dal.ca.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Lysosomal potassium channels.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lysosomal potassium channels.
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Membranes intracellulaires › Lysosomal potassium channels.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Lysosomal potassium channels.
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Lysosomal potassium channels.
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Lysosomal potassium channels.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Potassium › Lysosomal potassium channels.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Lysosomal potassium channels.