The RNA methyltransferase METTL8 installs m


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
11 01 2022
Historique:
received: 19 05 2021
accepted: 14 12 2021
entrez: 12 1 2022
pubmed: 13 1 2022
medline: 9 2 2022
Statut: epublish

Résumé

Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m

Identifiants

pubmed: 35017528
doi: 10.1038/s41467-021-27905-1
pii: 10.1038/s41467-021-27905-1
pmc: PMC8752778
doi:

Substances chimiques

Anticodon 0
RNA, Mitochondrial 0
RNA, Transfer, Ser 0
RNA, Transfer, Thr 0
Cytosine 8J337D1HZY
METTL8 protein, human EC 2.1.1.-
Methyltransferases EC 2.1.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

209

Informations de copyright

© 2022. The Author(s).

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Auteurs

Nicole Kleiber (N)

Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.

Nicolas Lemus-Diaz (N)

Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.

Carina Stiller (C)

Institute of Organic Chemistry, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.

Marleen Heinrichs (M)

Department of Cellular Biochemistry, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.

Mandy Mong-Quyen Mai (MM)

Department of Cellular Biochemistry, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.

Philipp Hackert (P)

Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.

Ricarda Richter-Dennerlein (R)

Department of Cellular Biochemistry, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.
Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), Göttingen, Germany.

Claudia Höbartner (C)

Institute of Organic Chemistry, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.

Katherine E Bohnsack (KE)

Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany. katherine.bohnsack@med.uni-goettingen.de.

Markus T Bohnsack (MT)

Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany. markus.bohnsack@med.uni-goettingen.de.
Cluster of Excellence "Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells" (MBExC), Göttingen, Germany. markus.bohnsack@med.uni-goettingen.de.
Göttingen Center for Molecular Biosciences, Georg-August University Göttingen, Justus-von-Liebig-Weg 11, Göttingen, 37077, Germany. markus.bohnsack@med.uni-goettingen.de.

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Classifications MeSH