The "Immunoscore" in rectal cancer: could we search quality beyond quantity of life?
immunoscore
prognosis
radiochemotherapy
rectal cancer
watch and wait
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
09
2021
accepted:
26
09
2021
entrez:
12
1
2022
pubmed:
13
1
2022
medline:
13
1
2022
Statut:
epublish
Résumé
Because of the function and anatomical environment of the rectum, therapeutic strategies for local advanced rectal cancer (LARC) must deal with two challenging stressors that are a high-risk of local and distal recurrences and a high-risk of poor quality of life (QoL). Over the last three decades, advances in screening tests, therapies, and combined-modality treatment options and strategies have improved the prognosis of patients with LARC. However, owing to the heterogeneous nature of LARC and genetic status, the patient may not respond to a specific therapy and may be at increased risk of side-effects without the life-prolonging benefit. Indeed, each therapy can cause its own side-effects, which may worsen by a combination of treatments resulting in long-term poor QoL. In LARC, QoL has become even more essential with the increasing incidence of rectal cancer in young individuals. Herein, we analyzed the value of the Immunoscore-Biopsy (performed on tumor biopsy at diagnosis) in predicting outcomes, alone or in association with clinical and imaging data, for each therapy used in LARC.
Identifiants
pubmed: 35018217
doi: 10.18632/oncotarget.28100
pii: 28100
pmc: PMC8734641
doi:
Types de publication
Journal Article
Langues
eng
Pagination
18-31Informations de copyright
Copyright: © 2022 Kirilovsky et al.
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST J.G., F.P., A.K. and G.Z. have patents associated with the immune prognostic biomarkers. J.G. is co-founder of HalioDx biotech company. Immunoscore® a registered trade-mark from the National Institute of Health and Medical Research (INSERM) licensed to HalioDx. The other authors declare no conflicts of interest.
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