Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation.
bone regeneration
converse piezoelectric effect
mechanical stimulation
Journal
Bioelectricity
ISSN: 2576-3113
Titre abrégé: Bioelectricity
Pays: United States
ID NLM: 101747121
Informations de publication
Date de publication:
01 Dec 2021
01 Dec 2021
Historique:
entrez:
12
1
2022
pubmed:
13
1
2022
medline:
13
1
2022
Statut:
ppublish
Résumé
Serious bone injuries have devastating effects on the lives of patients including limiting working ability and high cost. Orthopedic implants can aid in healing injuries to an extent that exceeds the natural regenerative capabilities of bone to repair fractures or large bone defects. Autografts and allografts are the standard implants used, but disadvantages such as donor site complications, a limited quantity of transplantable bone, and high costs have led to an increased demand for synthetic bone graft substitutes. However, replicating the complex physiological properties of biological bone, much less recapitulating its complex tissue functions, is challenging. Extensive efforts to design biocompatible implants that mimic the natural healing processes in bone have led to the investigation of piezoelectric smart materials because the bone has natural piezoelectric properties. Piezoelectric materials facilitate bone regeneration either by accumulating electric charge in response to mechanical stress, which mimics bioelectric signals through the direct piezoelectric effect or by providing mechanical stimulation in response to electrical stimulation through the converse piezoelectric effect. Although both effects are beneficial, the converse piezoelectric effect can address bone atrophy from stress shielding and immobility by improving the mechanical response of a healing defect. Mechanical stimulation has a positive impact on bone regeneration by activating cellular pathways that increase bone formation and decrease bone resorption. This review will highlight the potential of the converse piezoelectric effect to enhance bone regeneration by discussing the activation of beneficial cellular pathways, the properties of piezoelectric biomaterials, and the potential for the more effective administration of the converse piezoelectric effect using wireless control.
Identifiants
pubmed: 35018335
doi: 10.1089/bioe.2021.0019
pii: 10.1089/bioe.2021.0019
pmc: PMC8742263
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
255-271Subventions
Organisme : NIGMS NIH HHS
ID : T34 GM131947
Pays : United States
Informations de copyright
© Amber Carter et al. 2021; Published by Mary Ann Liebert, Inc.
Déclaration de conflit d'intérêts
No competing financial interests exist.
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