Immunity to SARS-CoV-2 up to 15 months after infection.
Immune response
Immunology
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
18 Feb 2022
18 Feb 2022
Historique:
received:
15
10
2021
revised:
20
12
2021
accepted:
05
01
2022
pubmed:
13
1
2022
medline:
13
1
2022
entrez:
12
1
2022
Statut:
ppublish
Résumé
Information concerning the longevity of immunity to SARS-CoV-2 following natural infection may have considerable implications for durability of immunity induced by vaccines. Here, we monitored the SARS-CoV-2 specific immune response in COVID-19 patients followed up to 15 months after symptoms onset. Following a peak at day 15-28 postinfection, the IgG antibody response and plasma neutralizing titers gradually decreased over time but stabilized after 6 months. Compared to G614, plasma neutralizing titers were more than 8-fold lower against variants Beta, Gamma, and Delta. SARS-CoV-2-specific memory B and T cells persisted in the majority of patients up to 15 months although a significant decrease in specific T cells, but not B cells, was observed between 6 and 15 months. Antiviral specific immunity, especially memory B cells in COVID-19 convalescent patients, is long-lasting, but some variants of concern may at least partially escape the neutralizing activity of plasma antibodies.
Identifiants
pubmed: 35018336
doi: 10.1016/j.isci.2022.103743
pii: S2589-0042(22)00013-X
pmc: PMC8736281
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103743Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The other authors declare no competing interests.
Références
Cell. 2020 Nov 12;183(4):996-1012.e19
pubmed: 33010815
Sci Rep. 2020 Dec 7;10(1):21393
pubmed: 33288836
Euro Surveill. 2020 Jun;25(24):
pubmed: 32583766
J Clin Invest. 2020 Dec 1;130(12):6477-6489
pubmed: 32833687
J Clin Microbiol. 2020 Aug 24;58(9):
pubmed: 32580948
Science. 2021 Nov 19;374(6570):995-999
pubmed: 34648303
Med (N Y). 2021 Mar 12;2(3):281-295.e4
pubmed: 33589885
Lancet. 2021 Jun 26;397(10293):2461-2462
pubmed: 34139198
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Nat Med. 2003 Sep;9(9):1131-7
pubmed: 12925846
J Immunol. 2003 Nov 15;171(10):4969-73
pubmed: 14607890
Nature. 2020 Aug;584(7821):457-462
pubmed: 32668444
Lancet Microbe. 2021 Jul;2(7):e283-e284
pubmed: 33846703
Euro Surveill. 2020 Jan;25(3):
pubmed: 31992387
Cell. 2020 Oct 1;183(1):158-168.e14
pubmed: 32979941
J Clin Microbiol. 2020 Oct 21;58(11):
pubmed: 32826322
Lancet Microbe. 2021 Jun;2(6):e240-e249
pubmed: 33778792
Nat Med. 2020 Jul;26(7):1033-1036
pubmed: 32398876
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Front Immunol. 2021 Jun 16;12:708523
pubmed: 34220870
Cell Rep Med. 2021 Jul 20;2(7):100354
pubmed: 34250512
BMJ. 2021 Jun 15;373:n1513
pubmed: 34130949
Viruses. 2020 Feb 25;12(3):
pubmed: 32106567
Cell. 2021 Jan 7;184(1):169-183.e17
pubmed: 33296701
Nat Rev Genet. 2021 Dec;22(12):757-773
pubmed: 34535792
Cell Rep. 2021 Jul 27;36(4):109433
pubmed: 34273271
Cell Rep. 2021 Feb 9;34(6):108728
pubmed: 33516277
Nat Med. 2020 Nov;26(11):1691-1693
pubmed: 32929268
Sci Immunol. 2020 Dec 7;5(54):
pubmed: 33288645
J Infect. 2021 Apr;82(4):e11-e12
pubmed: 33450303
Biochim Biophys Acta Mol Basis Dis. 2020 Oct 1;1866(10):165878
pubmed: 32544429
N Engl J Med. 2021 Feb 11;384(6):533-540
pubmed: 33369366
Cell Host Microbe. 2021 Apr 14;29(4):516-521.e3
pubmed: 33798491
PLoS One. 2015 Jun 05;10(6):e0128714
pubmed: 26046523
Cell Host Microbe. 2021 Mar 10;29(3):477-488.e4
pubmed: 33535027
Science. 2021 Apr 9;372(6538):
pubmed: 33658326
Cell Host Microbe. 2021 May 12;29(5):747-751.e4
pubmed: 33887205
Lancet. 2021 Feb 6;397(10273):452-455
pubmed: 33515491
Nature. 2021 Aug;596(7871):276-280
pubmed: 34237773
Cell Rep Med. 2021 Jun 15;2(6):100290
pubmed: 33969322
Science. 2020 Dec 4;370(6521):1227-1230
pubmed: 33115920
Nat Med. 2021 Jul;27(7):1205-1211
pubmed: 34002089
Science. 2021 Feb 5;371(6529):
pubmed: 33408181
Nature. 2021 May;593(7858):270-274
pubmed: 33723411
Cell Rep Med. 2021 Apr 20;2(4):100255
pubmed: 33842902
Lancet. 2021 Mar 27;397(10280):1204-1212
pubmed: 33743221
PLoS One. 2019 Jun 6;14(6):e0217878
pubmed: 31170233
Viruses. 2021 Apr 29;13(5):
pubmed: 33946747
Sci Immunol. 2020 Dec 22;5(54):
pubmed: 33443036
Nat Med. 2021 Apr;27(4):717-726
pubmed: 33664494
AIDS. 2010 May 15;24(8):1095-105
pubmed: 20400885
N Engl J Med. 2021 Oct 14;385(16):1474-1484
pubmed: 34320281
Lancet Infect Dis. 2021 Aug;21(8):1070
pubmed: 34022142
Nat Immunol. 2020 Nov;21(11):1336-1345
pubmed: 32887977
Nat Commun. 2020 Sep 17;11(1):4704
pubmed: 32943637
Nature. 2021 Jul;595(7867):426-431
pubmed: 34126625
N Engl J Med. 2020 Sep 10;383(11):1085-1087
pubmed: 32706954
Med (N Y). 2021 Mar 12;2(3):313-320.e4
pubmed: 33554155
Lancet. 2020 Nov 14;396(10262):1595-1606
pubmed: 33065034
Sci Immunol. 2021 Apr 15;6(58):
pubmed: 33858945
N Engl J Med. 2021 Jun 17;384(24):2354-2356
pubmed: 33822491
Nature. 2021 Jul;595(7867):421-425
pubmed: 34030176
Cell Host Microbe. 2021 Jul 14;29(7):1063-1075
pubmed: 34174992
JAMA Intern Med. 2021 May 1;181(5):672-679
pubmed: 33625463