Anti-Pythium insidiosum activity of MSI-78, LL-37, and magainin-2 antimicrobial peptides.
Antimicrobial peptides
LL-37
MSI-78
Magainin-2
Pythium insidiosum
Journal
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
ISSN: 1678-4405
Titre abrégé: Braz J Microbiol
Pays: Brazil
ID NLM: 101095924
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
24
10
2021
accepted:
31
12
2021
pubmed:
13
1
2022
medline:
3
3
2022
entrez:
12
1
2022
Statut:
ppublish
Résumé
We investigated the anti-Pythium insidiosum activity of the antimicrobial peptides (AMPs) MSI-78, LL-37, and magainin-2. To detect the minimum inhibitory concentration (MIC), fourteen clinical strains were incubated with the AMPs following the CLSI M38-A2 protocol. All three AMPs showed antimicrobial activity with an MIC range of 20-80 mg/L against all strains. We concluded that the evaluated AMPs have great potential as anti-Pythium insidiosum agents, and their activity deserves to be more explored in further research. Antimicrobial peptides were tested against Pythium insidiosum, a microorganism that causes a difficult-to-treat disease in animals and humans. These peptides have been shown to be able to kill P. insidiosum and may be candidates for use in the treatment of this infection.
Identifiants
pubmed: 35018604
doi: 10.1007/s42770-022-00678-5
pii: 10.1007/s42770-022-00678-5
pmc: PMC8882752
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Antimicrobial Peptides
0
Magainins
0
pexiganan
TVF29Q70Q1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
509-512Subventions
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 406170/2018-5
Informations de copyright
© 2022. The Author(s) under exclusive licence to Sociedade Brasileira de Microbiologia.
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