The metabolome as a biomarker of aging in Drosophila melanogaster.
aging
biomarker
drosophila
metabolomics
mortality
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
30
08
2021
accepted:
12
11
2021
pubmed:
13
1
2022
medline:
5
4
2022
entrez:
12
1
2022
Statut:
ppublish
Résumé
Many biomarkers have been shown to be associated not only with chronological age but also with functional measures of biological age. In human populations, it is difficult to show whether variation in biological age is truly predictive of life expectancy, as such research would require longitudinal studies over many years, or even decades. We followed adult cohorts of 20 Drosophila Genetic Reference Panel (DGRP) strains chosen to represent the breadth of lifespan variation, obtain estimates of lifespan, baseline mortality, and rate of aging, and associate these parameters with age-specific functional traits including fecundity and climbing activity and with age-specific targeted metabolomic profiles. We show that activity levels and metabolome-wide profiles are strongly associated with age, that numerous individual metabolites show a strong association with lifespan, and that the metabolome provides a biological clock that predicts not only sample age but also future mortality rates and lifespan. This study with 20 genotypes and 87 metabolites, while relatively small in scope, establishes strong proof of principle for the fly as a powerful experimental model to test hypotheses about biomarkers and aging and provides further evidence for the potential value of metabolomic profiles as biomarkers of aging.
Identifiants
pubmed: 35019203
doi: 10.1111/acel.13548
pmc: PMC8844127
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13548Subventions
Organisme : NIGMS NIH HHS
ID : R24 GM141156
Pays : United States
Organisme : NIGMS NIH HHS
ID : R24GM141156
Pays : United States
Organisme : NIEHS NIH HHS
ID : U2CES030167
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103533
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41GM103533
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG013280
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG049494
Pays : United States
Informations de copyright
© 2022 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
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