Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls.
6-glucan
Candida
Kre6
Skn1
antifungal
jervine
β-1
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
23 02 2022
23 02 2022
Historique:
pubmed:
13
1
2022
medline:
3
3
2022
entrez:
12
1
2022
Statut:
ppublish
Résumé
The limited number of available effective agents necessitates the development of new antifungals. We report that jervine, a jerveratrum-type steroidal alkaloid isolated from Veratrum californicum, has antifungal activity. Phenotypic comparisons of cell wall mutants, K1 killer toxin susceptibility testing, and quantification of cell wall components revealed that β-1,6-glucan biosynthesis was significantly inhibited by jervine. Temperature-sensitive mutants defective in essential genes involved in β-1,6-glucan biosynthesis, including
Identifiants
pubmed: 35019680
doi: 10.1128/spectrum.00873-21
pmc: PMC8754110
doi:
Substances chimiques
Alkaloids
0
Antifungal Agents
0
Plant Extracts
0
beta-Glucans
0
beta-1,6-glucan
37361-00-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0087321Références
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