Effect of Lumenato oral supplementation on plasma carotenoid levels and improvement of visual and experiential skin attributes.
anti aging
carotenes
phytoene
phytofluene
wrinkles
Journal
Journal of cosmetic dermatology
ISSN: 1473-2165
Titre abrégé: J Cosmet Dermatol
Pays: England
ID NLM: 101130964
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
16
12
2021
received:
29
11
2021
accepted:
22
12
2021
pubmed:
13
1
2022
medline:
28
9
2022
entrez:
12
1
2022
Statut:
ppublish
Résumé
Cellular metabolism and exposure to solar irradiation result in generation of free radicals which are destructive and can lead to premature aging. Antioxidants and free radical scavengers such as carotenoids successfully protect from these free radicals by quenching and neutralizing them thereby strengthening skin barrier which leads to improved skin moisturization, desquamation, and a more youthful look. This study was designed to evaluate the consumer-perceived efficacy of an oral supplement (Lumenato™) containing a mix of tomato carotenoids and oil-soluble vitamins in improving skin appearance after 12 weeks of supplement use. Plasma levels of phytoene, phytofluene, zeta-carotene, and lycopene were quantitated before and after 1-, 2-, 3-, and 4-week administration of Lumenato by 24 healthy volunteers. Part II of the study addressed skin visual attributes as assessed by validated tools (questionnaires). A total of 60 females, aged 35 to 55 years, completed part II of the study. The subjects answered questionnaires pertaining to their assessment of skin appearance before and after 12 weeks of taking the supplement. There was a significant increase (p < 0.001) in plasma levels of phytoene, phytofluene, and zeta-carotene after 1- to 4-week treatment with Lumenato. After 12 weeks of using the supplement, the score of different skin parameters was reported to significantly improve (p < 0.001). Improvement was recorded in skin elasticity, firmness, brightness, skin tone, reduction in dark spots and periorbital dark circles, skin hydration, texture and fine lines and wrinkles. A significant (p < 0.001) improvement in overall skin condition after using the supplement was observed. The subjects noticed statistically significant (p < 0.001) improvement in skin elasticity, firmness, brightness, skin tone, reduction in dark spots and periorbital dark circles, skin hydration, texture and fine lines and wrinkles after 12 weeks of using the supplement. The overall skin condition also exhibited a significant improvement (p < 0.001). Self-assessed improvement of the face was identified at the first time point (4 weeks) and improved significantly (p < 0.001) for the 12 weeks of use. Interestingly, these improvements persisted even after treatment was stopped. Based on the confines and conditions of this study, the use of oral supplement containing a mix of tomato carotenoids significantly increased plasma levels of phytoene, phytofluene, and zeta-carotene, and continuous use resulted in improved facial skin attributes which were palpable by the consumers and continued even after treatment was stopped.
Sections du résumé
BACKGROUND
BACKGROUND
Cellular metabolism and exposure to solar irradiation result in generation of free radicals which are destructive and can lead to premature aging. Antioxidants and free radical scavengers such as carotenoids successfully protect from these free radicals by quenching and neutralizing them thereby strengthening skin barrier which leads to improved skin moisturization, desquamation, and a more youthful look. This study was designed to evaluate the consumer-perceived efficacy of an oral supplement (Lumenato™) containing a mix of tomato carotenoids and oil-soluble vitamins in improving skin appearance after 12 weeks of supplement use.
MATERIALS AND METHODS
METHODS
Plasma levels of phytoene, phytofluene, zeta-carotene, and lycopene were quantitated before and after 1-, 2-, 3-, and 4-week administration of Lumenato by 24 healthy volunteers. Part II of the study addressed skin visual attributes as assessed by validated tools (questionnaires). A total of 60 females, aged 35 to 55 years, completed part II of the study. The subjects answered questionnaires pertaining to their assessment of skin appearance before and after 12 weeks of taking the supplement.
RESULTS
RESULTS
There was a significant increase (p < 0.001) in plasma levels of phytoene, phytofluene, and zeta-carotene after 1- to 4-week treatment with Lumenato. After 12 weeks of using the supplement, the score of different skin parameters was reported to significantly improve (p < 0.001). Improvement was recorded in skin elasticity, firmness, brightness, skin tone, reduction in dark spots and periorbital dark circles, skin hydration, texture and fine lines and wrinkles. A significant (p < 0.001) improvement in overall skin condition after using the supplement was observed. The subjects noticed statistically significant (p < 0.001) improvement in skin elasticity, firmness, brightness, skin tone, reduction in dark spots and periorbital dark circles, skin hydration, texture and fine lines and wrinkles after 12 weeks of using the supplement. The overall skin condition also exhibited a significant improvement (p < 0.001). Self-assessed improvement of the face was identified at the first time point (4 weeks) and improved significantly (p < 0.001) for the 12 weeks of use. Interestingly, these improvements persisted even after treatment was stopped.
CONCLUSION
CONCLUSIONS
Based on the confines and conditions of this study, the use of oral supplement containing a mix of tomato carotenoids significantly increased plasma levels of phytoene, phytofluene, and zeta-carotene, and continuous use resulted in improved facial skin attributes which were palpable by the consumers and continued even after treatment was stopped.
Identifiants
pubmed: 35020247
doi: 10.1111/jocd.14724
pmc: PMC9786813
doi:
Substances chimiques
Free Radical Scavengers
0
Vitamins
0
zeta Carotene
0
Carotenoids
36-88-4
phytofluene
6NUO4W7YQ6
(all-E) phytoene
87E4NJ6N51
Lycopene
SB0N2N0WV6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4042-4052Subventions
Organisme : Lycored
Informations de copyright
© 2021 Lycored LTD. Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.
Références
J Invest Dermatol. 1999 Dec;113(6):1128-32
pubmed: 10594762
J Nutr. 1989 Jan;119(1):101-4
pubmed: 2643690
J Nutr. 2007 Dec;137(12):2653-9
pubmed: 18029479
J Cosmet Dermatol. 2022 Sep;21(9):4042-4052
pubmed: 35020247
J Nutr. 1995 Jul;125(7):1854-9
pubmed: 7616301
Dermatology. 2001;202(4):289-92
pubmed: 11455139
Am J Clin Nutr. 1991 Jan;53(1 Suppl):373S-379S
pubmed: 1985414
Ann N Y Acad Sci. 2000 Jun;908:219-25
pubmed: 10911961
Free Radic Res. 1996 Mar;24(3):215-24
pubmed: 8728123
J Biol Chem. 1997 Aug 15;272(33):20313-6
pubmed: 9252331
J Invest Dermatol. 1983 Jun;80 Suppl:44s-49s
pubmed: 6189923
J Agric Food Chem. 2005 Jun 15;53(12):5041-8
pubmed: 15941354
Mutat Res. 1992 Sep;275(3-6):257-66
pubmed: 1383768
Photodermatol Photoimmunol Photomed. 1999 Jun-Aug;15(3-4):115-9
pubmed: 10404721
Dermatol Clin. 2009 Oct;27(4):529-33, viii
pubmed: 19850202
Exp Dermatol. 2008 Aug;17(8):653-8
pubmed: 18312382
Free Radic Biol Med. 1998 Nov 1;25(7):848-73
pubmed: 9823551
J Invest Dermatol. 1994 Jan;102(1):122-4
pubmed: 8288904
J Invest Dermatol. 1990 Oct;95(4):403-8
pubmed: 2212725
Annu Rev Med. 1996;47:181-91
pubmed: 8712772
Histochem J. 1982 Jul;14(4):573-84
pubmed: 6181018
Skin Pharmacol Physiol. 2019;32(2):101-108
pubmed: 30836363
PLoS One. 2021 Mar 17;16(3):e0248183
pubmed: 33730073
J Invest Dermatol. 1994 Nov;103(5):731-41
pubmed: 7963664
Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):340-5
pubmed: 15006906
Hautarzt. 2001 Jan;52(1):62-3
pubmed: 11220243
Arch Biochem Biophys. 1989 Nov 1;274(2):532-8
pubmed: 2802626
J Invest Dermatol. 2010 Feb;130(2):629-31
pubmed: 19812595
Am J Clin Nutr. 1996 Oct;64(4):594-602
pubmed: 8839505
J Invest Dermatol. 1998 May;110(5):756-61
pubmed: 9579541
Science. 1992 Aug 28;257(5074):1220-4
pubmed: 1355616
J Biol Chem. 1987 Apr 25;262(12):5488-91
pubmed: 3571220
Skin Pharmacol Physiol. 2009;22(6):299-304
pubmed: 19786823
Antioxid Redox Signal. 2013 Sep 10;19(8):779-87
pubmed: 23841595
J Toxicol. 2018 Apr 15;2018:5475784
pubmed: 29849613
Br J Dermatol. 2001 Jun;144(6):1161-8
pubmed: 11422036
Photochem Photobiol. 1991 May;53(5):707-16
pubmed: 1881965
Int J Dermatol. 2004 May;43(5):326-35
pubmed: 15117361
Int J Vitam Nutr Res. 2005 Jan;75(1):54-60
pubmed: 15830922
Biochem J. 2007 Jan 1;401(1):1-11
pubmed: 17150040
J Nutr. 2003 Jan;133(1):98-101
pubmed: 12514275
Physiol Rev. 2002 Jan;82(1):47-95
pubmed: 11773609
Photochem Photobiol Sci. 2004 Aug;3(8):749-52
pubmed: 15295630
J Nutr. 2005 May;135(5):1226-30
pubmed: 15867308
Exp Biol Med (Maywood). 2004 Sep;229(8):765-71
pubmed: 15337830
Environ Health Perspect. 1998 Oct;106 Suppl 5:1241-51
pubmed: 9788905
Mol Aspects Med. 2003 Dec;24(6):345-51
pubmed: 14585305
Exp Dermatol. 2019 Sep;28(9):1044-1050
pubmed: 31287602
J Drugs Dermatol. 2008 Jul;7(7 Suppl):s7-12
pubmed: 18681153
Skin Pharmacol Physiol. 2009;22(1):31-44
pubmed: 19122479
Food Chem. 2017 Aug 15;229:304-311
pubmed: 28372178
Br J Nutr. 2003 Oct;90(4):759-66
pubmed: 13129444
Exp Dermatol. 2011 May;20(5):377-82
pubmed: 21366698
Clin Chem. 1993 May;39(5):810-4
pubmed: 8485871
Arch Biochem Biophys. 2015 Apr 15;572:188-200
pubmed: 25615528
J Nutr. 2005 Aug;135(8):2030S-1S
pubmed: 16046732
Skin Res Technol. 1996 May;2(2):59-63
pubmed: 27327219
Curr Probl Dermatol. 2001;29:26-42
pubmed: 11225199
Am J Clin Nutr. 2000 Mar;71(3):795-8
pubmed: 10702175