Charge Matters: Mutations in Omicron Variant Favor Binding to Cells.
Journal
Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360
Informations de publication
Date de publication:
18 03 2022
18 03 2022
Historique:
revised:
11
01
2022
received:
14
12
2021
pubmed:
13
1
2022
medline:
29
3
2022
entrez:
12
1
2022
Statut:
ppublish
Résumé
Evidence is strengthening to suggest that the novel SARS-CoV-2 mutant Omicron, with its more than 60 mutations, will spread and dominate worldwide. Although the mutations in the spike protein are known, the molecular basis for why the additional mutations in the spike protein that have not previously occurred account for Omicron's higher infection potential, is not understood. We propose, based on chemical rational and molecular dynamics simulations, that the elevated occurrence of positively charged amino acids in certain domains of the spike protein (Delta: +4; Omicron: +5 vs. wild type) increases binding to cellular polyanionic receptors, such as heparan sulfate due to multivalent charge-charge interactions. This observation is a starting point for targeted drug development.
Identifiants
pubmed: 35020256
doi: 10.1002/cbic.202100681
pmc: PMC9015620
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202100681Subventions
Organisme : EXIST
Organisme : Berlin University Alliance G2 Global Health
Organisme : IRTG 2662
Informations de copyright
© 2022 The Authors. ChemBioChem published by Wiley-VCH GmbH.
Références
Nat Commun. 2021 Oct 20;12(1):6103
pubmed: 34671049
Cell. 2021 Jun 24;184(13):3426-3437.e8
pubmed: 33991487
Chembiochem. 2022 Mar 18;23(6):e202100681
pubmed: 35020256
Cell. 2022 Feb 17;185(4):630-640.e10
pubmed: 35093192
Cell. 2020 Nov 12;183(4):1043-1057.e15
pubmed: 32970989
Science. 2021 Apr 30;372(6541):525-530
pubmed: 33727252
Cell Host Microbe. 2021 Jan 13;29(1):44-57.e9
pubmed: 33259788
J Cheminform. 2012 Aug 13;4(1):17
pubmed: 22889332
Antiviral Res. 2020 Sep;181:104873
pubmed: 32653452
Angew Chem Int Ed Engl. 2021 Feb 19;60(8):3882-3904
pubmed: 32589355
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
Nat Rev Microbiol. 2021 Jul;19(7):409-424
pubmed: 34075212
Nature. 2022 Feb;602(7898):664-670
pubmed: 35016195
Mol Biosyst. 2017 May 2;13(5):852-865
pubmed: 28317949
J Virus Erad. 2021 Sep;7(3):100054
pubmed: 34548928
Arteriosclerosis. 1989 Jan-Feb;9(1):21-32
pubmed: 2463827
Nat Med. 2021 May;27(5):917-924
pubmed: 33772244
Biophys J. 2021 Mar 16;120(6):1060-1071
pubmed: 33484712
Cell. 2021 Apr 29;184(9):2348-2361.e6
pubmed: 33730597
Nature. 2021 Aug;596(7871):276-280
pubmed: 34237773
Chembiochem. 2021 Feb 15;22(4):724-732
pubmed: 32986926
Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41
pubmed: 11517324
J Clin Microbiol. 2021 Oct 19;59(11):e0092121
pubmed: 34379531
Nature. 2022 Feb;602(7896):300-306
pubmed: 34823256
Nat Med. 2021 Apr;27(4):717-726
pubmed: 33664494
Viruses. 2019 Jul 01;11(7):
pubmed: 31266258
Nature. 2022 Mar;603(7902):715-720
pubmed: 35104836
ACS Cent Sci. 2021 Jun 23;7(6):1009-1018
pubmed: 34235261
Front Immunol. 2021 Nov 05;12:744242
pubmed: 34804024
Angew Chem Int Ed Engl. 2021 Jul 12;60(29):15870-15878
pubmed: 33860605