Thrombotic Risk Determined by Protein C Receptor (PROCR) Variants among Middle-Aged and Older Adults: A Population-Based Cohort Study.

Aged Cohort Studies Endothelial Protein C Receptor / genetics Female Genome-Wide Association Study Humans Male Middle Aged Protein C / genetics Risk Factors Thrombosis / epidemiology Venous Thromboembolism / epidemiology

Journal

Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063

Informations de publication

Date de publication:
Aug 2022
Historique:
pubmed: 13 1 2022
medline: 24 8 2022
entrez: 12 1 2022
Statut: ppublish

Résumé

 The protein C (PC) anticoagulant system has a key role in maintaining hemostatic balance. One missense (Ser219Gly) variant in the PC receptor (  This study aimed to determine the thrombotic risk of rare and common  The exonic sequence of  Re-sequencing identified 36  Homozygosity for the Ser219Gly variant and a previously identified functional

Sections du résumé

BACKGROUND BACKGROUND
 The protein C (PC) anticoagulant system has a key role in maintaining hemostatic balance. One missense (Ser219Gly) variant in the PC receptor (
OBJECTIVES OBJECTIVE
 This study aimed to determine the thrombotic risk of rare and common
METHODS METHODS
 The exonic sequence of
RESULTS RESULTS
 Re-sequencing identified 36
CONCLUSION CONCLUSIONS
 Homozygosity for the Ser219Gly variant and a previously identified functional

Identifiants

DOI: 10.1055/a-1738-1564 PMID: 35021256
pubmed: 35021256
doi: 10.1055/a-1738-1564
doi:

Substances chimiques

Endothelial Protein C Receptor 0
PROCR protein, human 0
Protein C 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1326-1332

Informations de copyright

Thieme. All rights reserved.

Déclaration de conflit d'intérêts

None declared.

Auteurs

Eric Manderstedt (E)

Department of Environmental Science and Bioscience, Kristianstad University, Kristianstad, Sweden.

Christer Halldén (C)

Department of Environmental Science and Bioscience, Kristianstad University, Kristianstad, Sweden.

Christina Lind-Halldén (C)

Department of Environmental Science and Bioscience, Kristianstad University, Kristianstad, Sweden.

Johan Elf (J)

Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden.

Peter J Svensson (PJ)

Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden.

Gunnar Engström (G)

Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden.

Olle Melander (O)

Department of Clinical Sciences, Skåne University Hospital, Lund University, Malmö, Sweden.

Aris Baras (A)

Regeneron Genetics Center, Tarrytown, New York, United States.

Luca A Lotta (LA)

Regeneron Genetics Center, Tarrytown, New York, United States.

Bengt Zöller (B)

Center for Primary Health Care Research, Lund University and Region Skåne, Malmö, Sweden.
ORCID: 0000-0002-8250-5613

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteur endothélial de la protéine C › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Facteurs biologiques › Inhibiteurs des facteurs de la coagulation sanguine › Protéine C › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Thrombotic Risk Determined by Protein C...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thromboembolie › Thromboembolisme veineux › Thrombotic Risk Determined by Protein C...