Synthesis, In Silico Studies, and Biological Evaluation of 1,3,4-Oxadiazino Indole Derivatives.
CNS activity
Docking study
Indole drrivatives
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
13
1
2022
pubmed:
14
1
2022
medline:
15
1
2022
Statut:
ppublish
Résumé
New series of substituted 2-[4-pyridyl](1,3,4)oxadiazino(5,6-b)indole derivatives were synthesized and evaluated for in silico studies. Based on in silico studies, the selected compounds were synthesized and evaluated for their antidepressant activity by forced swim test. Among these compounds, compound IVD was found to be most potent antidepressant-like activity and significantly reduced the duration of immobility at 100 mg/kg dose level when compared to the vehicle control which is similar to the reference drug imipramine (10 mg/kg).
Identifiants
pubmed: 35023111
doi: 10.1007/978-3-030-78787-5_29
doi:
Substances chimiques
Antidepressive Agents
0
Antipsychotic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-248Informations de copyright
© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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