Tumor-associated immune cell infiltrate density in penile squamous cell carcinomas.
Antibodies
Penile carcinomas
Tissue microarray
Tumor microenvironment
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
13
10
2021
accepted:
04
01
2022
revised:
03
01
2022
pubmed:
14
1
2022
medline:
14
6
2022
entrez:
13
1
2022
Statut:
ppublish
Résumé
Penile squamous cell carcinomas are rare tumor entities throughout Europe. Early lymphonodal spread urges for aggressive therapeutic approaches in advanced tumor stages. Therefore, understanding tumor biology and its microenvironment and correlation with known survival data is of substantial interest in order to establish treatment strategies adapted to the individual patient. Fifty-five therapy naïve squamous cell carcinomas, age range between 41 and 85 years with known clinicopathological data, were investigated with the use of tissue microarrays (TMA) regarding the tumor-associated immune cell infiltrate density (ICID). Slides were stained with antibodies against CD3, CD8 and CD20. An image analysis software was applied for evaluation. Data were correlated with clinicopathological characteristics and overall survival. There was a significant increase of ICID in squamous cell carcinomas of the penis in relation to tumor adjacent physiological tissue. Higher CD3-positive ICID was significantly associated with lower tumor stage in our cohort. The ICID was not associated with overall survival. Our data sharpens the view on tumor-associated immune cell infiltrate in penile squamous cell carcinomas with an unbiased digital and automated cell count. Further investigations on the immune cell infiltrate and its prognostic and possible therapeutic impact are needed.
Identifiants
pubmed: 35024940
doi: 10.1007/s00428-022-03271-1
pii: 10.1007/s00428-022-03271-1
pmc: PMC9184419
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1159-1169Informations de copyright
© 2022. The Author(s).
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