The health status: the ignored risk factor in dementia incidence. NEDICES cohort.
Dementia and Alzheimer risk
Dementia prevention
Education
Health status
Physical activity
Self-perceived health
Journal
Aging clinical and experimental research
ISSN: 1720-8319
Titre abrégé: Aging Clin Exp Res
Pays: Germany
ID NLM: 101132995
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
12
07
2021
accepted:
28
11
2021
pubmed:
14
1
2022
medline:
3
6
2022
entrez:
13
1
2022
Statut:
ppublish
Résumé
The causes of the dementia decrease in affluent countries are not well known but health amelioration could probably play a major role. Nevertheless, although many vascular and systemic disorders in adult life are well-known risk factors (RF) for dementia and Alzheimer disease (AD), health status is rarely considered as a single RF. To analyse whether the health status and the self-perceived health (SPH) could be RF for dementia and AD and to discuss its biological basis. We analysed different objective health measures and SPH as RF for dementia and AD incidence in 4569 participants of the NEDICES cohort by means of Cox-regression models. The mean follow-up period was 3.2 (range: 0.03-6.6) years. Ageing, low education, history of stroke, and "poor" SPH were the main RF for dementia and AD incidence, whereas physical activity was protective. "Poor" SPH had a hazard ratio = 1.66 (95% CI 1.17-2.46; p = 0.012) after controlling for different confounders. According to data from NEDICES cohort, SPH is a better predictor of dementia and AD than other more objective health status proxies. SPH should be considered a holistic and biologically rooted indicator of health status, which can predict future development of dementia and AD in older adults. Our data indicate that it is worthwhile to include the SPH status as a RF in the studies of dementia and AD incidence and to explore the effect of its improvement in the evolution of this incidence.
Sections du résumé
BACKGROUND
BACKGROUND
The causes of the dementia decrease in affluent countries are not well known but health amelioration could probably play a major role. Nevertheless, although many vascular and systemic disorders in adult life are well-known risk factors (RF) for dementia and Alzheimer disease (AD), health status is rarely considered as a single RF.
AIM
OBJECTIVE
To analyse whether the health status and the self-perceived health (SPH) could be RF for dementia and AD and to discuss its biological basis.
METHODS
METHODS
We analysed different objective health measures and SPH as RF for dementia and AD incidence in 4569 participants of the NEDICES cohort by means of Cox-regression models. The mean follow-up period was 3.2 (range: 0.03-6.6) years.
RESULTS
RESULTS
Ageing, low education, history of stroke, and "poor" SPH were the main RF for dementia and AD incidence, whereas physical activity was protective. "Poor" SPH had a hazard ratio = 1.66 (95% CI 1.17-2.46; p = 0.012) after controlling for different confounders.
DISCUSSION
CONCLUSIONS
According to data from NEDICES cohort, SPH is a better predictor of dementia and AD than other more objective health status proxies. SPH should be considered a holistic and biologically rooted indicator of health status, which can predict future development of dementia and AD in older adults.
CONCLUSIONS
CONCLUSIONS
Our data indicate that it is worthwhile to include the SPH status as a RF in the studies of dementia and AD incidence and to explore the effect of its improvement in the evolution of this incidence.
Identifiants
pubmed: 35025095
doi: 10.1007/s40520-021-02045-0
pii: 10.1007/s40520-021-02045-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1275-1283Subventions
Organisme : instituto de salud carlos iii
ID : JR 18/00046
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
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