Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner.
biochemistry
chemical biology
developmental biology
fetal heart
heart metabolism
lipidomics
maternal obesity
mouse
transcriptomics
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
13 01 2022
13 01 2022
Historique:
received:
03
04
2021
accepted:
12
01
2022
pubmed:
14
1
2022
medline:
16
3
2022
entrez:
13
1
2022
Statut:
epublish
Résumé
Maternal obesity during pregnancy has immediate and long-term detrimental effects on the offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in late gestation E18.5 fetuses of diet-induced obese pregnant mice and established the changes in lipid abundance and fetal cardiac transcriptomics. We used untargeted and targeted lipidomics and transcriptomics to define changes in the serum and cardiac lipid composition and fatty acid metabolism in male and female fetuses. From these analyses we observed: (1) maternal obesity affects the maternal and fetal serum lipidome distinctly; (2) female fetal heart lipidomes are more sensitive to maternal obesity than males; (3) changes in lipid supply might contribute to early expression of lipolytic genes in mouse hearts exposed to maternal obesity. These results highlight the existence of sexually dimorphic responses of the fetal heart to the same in utero obesogenic environment and identify lipids species that might mediate programming of cardiovascular health.
Identifiants
pubmed: 35025731
doi: 10.7554/eLife.69078
pii: 69078
pmc: PMC8794468
doi:
pii:
Banques de données
GEO
['GSE162185']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MC_UU_12012/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00025/6
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/17/12/33167
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_G0902052
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/4
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 208363/Z/17/Z
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/18/56/35177
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/12/64/30001
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M027252/1
Pays : United Kingdom
Informations de copyright
© 2022, Pantaleão et al.
Déclaration de conflit d'intérêts
LP, II, SF, EL, AH, TA, HB, BJ, AC, AW, MB, AK, DF, SO No competing interests declared
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