Microvascular dysfunction in pediatric patients with SARS-COV-2 pneumonia: report of three severe cases.
COVID-19
Children
Coagulation
Newborns
Pediatric critical care
Sublingual microcirculation analysis
Journal
Microvascular research
ISSN: 1095-9319
Titre abrégé: Microvasc Res
Pays: United States
ID NLM: 0165035
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
11
06
2021
revised:
01
01
2022
accepted:
02
01
2022
pubmed:
14
1
2022
medline:
18
3
2022
entrez:
13
1
2022
Statut:
ppublish
Résumé
The coronavirus 19 (COVID-19) pandemic has affected hundreds of millions of people worldwide: in most of cases children and young people developed asymptomatic or pauci-symptomatic clinical pictures. However authors have showed that there are some categories of childhood more vulnerable to COVID-19 infection such as newborns or children with comorbidities. We report for the first time to the best of our knowledge about microvascular dysfunction in three pediatric clinical cases who developed COVID-19 infections with need of pediatric critical care. We found that sublingual microcirculation is altered in children with severe COVID-19 infection. Our findings confirmed most of data already observed by other authors in adult population affected by severe COVID-19 infection, but with distinct characteristics than microcirculation alterations previous observed in a clinical case of MIS-C. However we cannot establish direct correlation between microcirculation analysis and clinical or laboratory parameters in our series, by our experience we have found that sublingual microcirculation analysis allow clinicians to report directly about microcirculation dysfunction in COVID-19 patients and it could be a valuable bedside technique to monitor thrombosis complication in this population.
Identifiants
pubmed: 35026289
pii: S0026-2862(22)00002-4
doi: 10.1016/j.mvr.2022.104312
pmc: PMC8744301
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104312Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
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