Photodynamic therapy fortified with topical oleyl alcohol-based transethosomal 8-methoxypsoralen for ameliorating vitiligo: Optimization and clinical study.

Administration, Cutaneous Drug Delivery Systems Fatty Alcohols Humans Methoxsalen Photochemotherapy Skin Vitiligo / drug therapy
8-Methoxypsoralen Photodynamic therapy Transethosomes Transfersomes Vitiligo

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
25 Feb 2022
Historique:
received: 06 11 2021
revised: 24 12 2021
accepted: 05 01 2022
pubmed: 14 1 2022
medline: 9 2 2022
entrez: 13 1 2022
Statut: ppublish

Résumé

Vitiligo is a common autoimmune skin disorder that is characterized by patchy depigmentation of the skin due to melanocytes and melanin loss. Herein, photodynamic therapy mediated 8-methoxypsoralen (8-MOP), has been used fortified with topical oleyl alcohol-based transethosomes; to overcome the poor solubility and adverse effects associated with 8-MOP oral delivery. A 2

Identifiants

DOI: 10.1016/j.ijpharm.2022.121459 PMID: 35026313
pubmed: 35026313
pii: S0378-5173(22)00012-6
doi: 10.1016/j.ijpharm.2022.121459
pii:
doi:

Substances chimiques

Fatty Alcohols 0
oleyl alcohol 172F2WN8DV
Methoxsalen U4VJ29L7BQ

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

121459

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Dina B Mahmoud (DB)

Pharmaceutics Department, Egyptian Drug Authority formerly known as National Organization of Drug Control and Research, Egypt; Pharmaceutical Technology, Institute of Pharmacy, Leipzig University, Leipzig 04317, Germany. Electronic address: Dina.BahaaElDinMahmoudZaki@medizin.uni-leipzig.de.

Aliaa N ElMeshad (AN)

Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt; Department of Pharmaceutics, Faculty of Pharmacy and Drug Technology, The Egyptian Chinese University, Gesr El Suez St., PO 11786, Cairo, Egypt. Electronic address: aliaa.elmeshad@pharma.cu.edu.eg.

Maha Fadel (M)

Department of Medical Applications of Laser, Pharmaceutical Nanotechnology Unit, National Institute of Laser Enhanced Sciences, Cairo University, Cairo 12613, Egypt.

Abeer Tawfik (A)

Department of Medical Applications of Laser, Dermatology Unit, National Institute of Laser Enhanced Sciences, Cairo University, Cairo 12613, Egypt.

Shahenda A Ramez (SA)

Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt.

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie topique › Administration par voie cutanée › Photodynamic therapy fortified with topical...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Photodynamic therapy fortified with topical...
questionsmedicales.fr › Lipides › Alcools gras › Photodynamic therapy fortified with topical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Photodynamic therapy fortified with topical...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Furocoumarines › Méthoxsalène › Photodynamic therapy fortified with topical...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Photodynamic therapy fortified with topical...
questionsmedicales.fr › Système tégumentaire › Peau › Photodynamic therapy fortified with topical...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Hypopigmentation › Vitiligo › Photodynamic therapy fortified with topical...