Gut microbiota in patients with Alzheimer's disease spectrum: a systematic review and meta-analysis.
Alzheimer’s disease
dysbiosis
gut microbiota
meta-analysis
mild cognitive impairment
systematic review
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
14 01 2022
14 01 2022
Historique:
received:
27
08
2021
accepted:
20
12
2021
pubmed:
15
1
2022
medline:
5
2
2022
entrez:
14
1
2022
Statut:
ppublish
Résumé
Gut dysbiosis has been proposed as one of pathologies in patients with Alzheimer's disease (AD) spectrum. Despite such enthusiasm, the relevant results remain substantially controversial. A systematic review and meta-analysis were performed to investigate the differences of gut microbiota (GM) between patients with AD spectrum (including mild cognitive impairment [MCI] and AD) and healthy controls (HC). PubMed, MEDLINE, Scopus, and Cochrane Library from January 2000 to August 2021. Eligibility criteria for study selection: Observational trials and pre-intervention data of intervention trials that investigated the abundance of GM in patients with AD spectrum and HC. Two reviewers independently identified articles, extracted data, and evaluated the risk of bias. The effect sizes were performed by a random-effect, inverse-variance weighted model. The effects of different countries and of clinical stages on GM abundance were also examined. 11 studies consisting of 378 HC and 427 patients with AD spectrum were included in the meta-analysis. Patients with AD, but not MCI, showed significantly reduced GM diversity as compared to HC. We also found more abundance of The inclusion of studies originating only from China and the U.S. was a possible limitation. Patients with AD spectrum demonstrated altered GM abundance, which was differentially mediated by countries and clinical stages.
Identifiants
pubmed: 35027502
pii: 203826
doi: 10.18632/aging.203826
pmc: PMC8791218
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
477-496Références
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