Anemia, hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in burning mouth syndrome patients with normocytosis.
Anemia
Burning mouth syndrome
Hyperhomocysteinemia
Normocytosis
Vitamin B12 deficiency
Journal
Journal of dental sciences
ISSN: 2213-8862
Titre abrégé: J Dent Sci
Pays: Netherlands
ID NLM: 101293181
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
09
09
2021
entrez:
14
1
2022
pubmed:
15
1
2022
medline:
15
1
2022
Statut:
ppublish
Résumé
Normocytosis is defined as having the mean corpuscular volume (MCV) between 80 fL and 99.9 fL. This study evaluated whether 770 burning mouth syndrome (BMS) patients with normocytosis (so-called normocytosis/BMS patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 442 healthy control subjects or 884 BMS patients. Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 884 BMS patients (including 770 normocytosis/BMS patients) and 442 healthy control subjects were measured and compared. We found that 12.3%, 13.2%, 2.2%, 2.3%, 17.3%, and 10.5% of 770 normocytosis/BMS patients had blood hemoglobin (Hb), iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Furthermore, 770 normocytosis/BMS patients had significantly higher frequencies of blood Hb, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 442 healthy control subjects (all We conclude that there are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in normocytosis/BMS patients than in healthy control subjects. On the contrary, normocytosis/BMS patients do have significantly lower frequencies of blood Hb and vitamin B12 deficiencies than overall BMS patients.
Sections du résumé
BACKGROUND/PURPOSE
OBJECTIVE
Normocytosis is defined as having the mean corpuscular volume (MCV) between 80 fL and 99.9 fL. This study evaluated whether 770 burning mouth syndrome (BMS) patients with normocytosis (so-called normocytosis/BMS patients) had significantly higher frequencies of anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody (GPCA) positivity than 442 healthy control subjects or 884 BMS patients.
MATERIALS AND METHODS
METHODS
Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, and GPCA levels in 884 BMS patients (including 770 normocytosis/BMS patients) and 442 healthy control subjects were measured and compared.
RESULTS
RESULTS
We found that 12.3%, 13.2%, 2.2%, 2.3%, 17.3%, and 10.5% of 770 normocytosis/BMS patients had blood hemoglobin (Hb), iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity, respectively. Furthermore, 770 normocytosis/BMS patients had significantly higher frequencies of blood Hb, iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity than 442 healthy control subjects (all
CONCLUSION
CONCLUSIONS
We conclude that there are significantly higher frequencies of anemia, serum iron, vitamin B12, and folic acid deficiencies, hyperhomocysteinemia, and serum GPCA positivity in normocytosis/BMS patients than in healthy control subjects. On the contrary, normocytosis/BMS patients do have significantly lower frequencies of blood Hb and vitamin B12 deficiencies than overall BMS patients.
Identifiants
pubmed: 35028018
doi: 10.1016/j.jds.2021.09.025
pii: S1991-7902(21)00235-X
pmc: PMC8740384
doi:
Types de publication
Journal Article
Langues
eng
Pagination
35-41Informations de copyright
© 2021 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest relevant to this article.
Références
Hematology Am Soc Hematol Educ Program. 2012;2012:183-90
pubmed: 23233579
Am Fam Physician. 2000 Nov 15;62(10):2255-64
pubmed: 11126852
J Formos Med Assoc. 2014 Feb;113(2):83-7
pubmed: 24388269
J Formos Med Assoc. 2017 Aug;116(8):613-619
pubmed: 28314600
J Formos Med Assoc. 2019 Sep;118(9):1299-1307
pubmed: 31202497
Am J Clin Nutr. 2007 Jan;85(1):193-200
pubmed: 17209196
J Dent Sci. 2020 Mar;15(1):42-49
pubmed: 32256999
J Dent Sci. 2021 Mar;16(2):608-613
pubmed: 33854709
J Formos Med Assoc. 2021 Feb;120(2):819-826
pubmed: 32888843
J Dent Sci. 2020 Mar;15(1):34-41
pubmed: 32256998
Blood Rev. 2014 Mar;28(2):49-66
pubmed: 24560123
J Formos Med Assoc. 2015 Sep;114(9):806-12
pubmed: 26187724
Am Fam Physician. 1997 May 15;55(7):2455-62
pubmed: 9166144
J Dent Sci. 2021 Oct;16(4):1133-1139
pubmed: 34484580
Br Med J. 1962 Nov 24;2(5316):1347-52
pubmed: 13993616
Arch Pharm Res. 2018 Apr;41(4):372-383
pubmed: 29552692
J Formos Med Assoc. 2020 Apr;119(4):813-820
pubmed: 31679908
J Formos Med Assoc. 2020 Dec;119(12):1758-1763
pubmed: 32883568
J Dent Sci. 2021 Oct;16(4):1110-1116
pubmed: 34484577
Oral Dis. 2013 May;19(4):381-6
pubmed: 22957902
J Dent Sci. 2021 Jul;16(3):846-853
pubmed: 34141098
J Formos Med Assoc. 2016 Dec;115(12):1061-1068
pubmed: 27839675
Food Nutr Bull. 2008 Jun;29(2 Suppl):S238-44
pubmed: 18709899
N Engl J Med. 2006 Apr 13;354(15):1567-77
pubmed: 16531613
Alcohol Clin Exp Res. 2005 Mar;29(3):334-6
pubmed: 15770107
J Formos Med Assoc. 2015 Jun;114(6):532-8
pubmed: 25886860
J Dent Sci. 2020 Jun;15(2):214-221
pubmed: 32595904
J Environ Pathol Toxicol Oncol. 2018;37(3):241-259
pubmed: 30317974
J Formos Med Assoc. 2018 Dec;117(12):1065-1071
pubmed: 30087017
J Formos Med Assoc. 2018 Mar;117(3):227-234
pubmed: 29292055
Lancet. 1959 Aug 15;2(7094):106-8
pubmed: 13837172
Alcohol Alcohol. 2001 May-Jun;36(3):189-92
pubmed: 11373253
J Oral Pathol Med. 2016 Jan;45(1):23-7
pubmed: 25990467
Am Fam Physician. 2003 Mar 1;67(5):979-86
pubmed: 12643357
World J Gastroenterol. 2009 Nov 7;15(41):5121-8
pubmed: 19891010
J Formos Med Assoc. 2015 Aug;114(8):736-41
pubmed: 25935499
Arch Intern Med. 1999 Jun 28;159(12):1289-98
pubmed: 10386505