Potential of Withaferin-A, Withanone and Caffeic Acid Phenethyl ester as ATP-competitive inhibitors of BRAF: A bioinformatics study.
ATP-Competitive inhibitors and cancer
BRAF
BRAF V600E mutant
Caffeic acid phenethyl ester
Withaferin-A
Withanone
Journal
Current research in structural biology
ISSN: 2665-928X
Titre abrégé: Curr Res Struct Biol
Pays: Netherlands
ID NLM: 101767537
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
03
2021
revised:
09
11
2021
accepted:
10
11
2021
entrez:
14
1
2022
pubmed:
15
1
2022
medline:
15
1
2022
Statut:
epublish
Résumé
Serine/threonine-protein kinase B-raf (BRAF) plays a significant role in regulating cell division and proliferation through MAPK/ERK pathway. The constitutive expression of wild-type BRAF (BRAF
Identifiants
pubmed: 35028596
doi: 10.1016/j.crstbi.2021.11.004
pii: S2665-928X(21)00027-1
pmc: PMC8714769
doi:
Types de publication
Journal Article
Langues
eng
Pagination
301-311Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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