Role of therapeutic endoscopic ultrasound in gastrointestinal malignancy- current evidence and future directions.
Biliary drainage
Celiac plexus neurolysis
Gastrojejunostomy
Immunotherapy
Tumor ablation
Journal
Clinical journal of gastroenterology
ISSN: 1865-7265
Titre abrégé: Clin J Gastroenterol
Pays: Japan
ID NLM: 101477246
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
28
05
2021
accepted:
11
11
2021
pubmed:
15
1
2022
medline:
23
2
2022
entrez:
14
1
2022
Statut:
ppublish
Résumé
Endoscopic ultrasound (EUS) has come a long way from a mere diagnostic tool to an advanced therapeutic modality. With the advent of better technologies and accessories, EUS has found ground in the management of gastrointestinal (GI) malignancies, not only for diagnosis but also for therapeutic purposes. EUS can tackle a host of conditions, including hepato-pancreatico-biliary malignancies. Advances and experience in various EUS-guided biliary drainage techniques have enabled the endosonologist to tackle biliary obstruction when conventional techniques of endoscopic retrograde cholangiopancreatography (ERCP) and/or percutaneous transhepatic biliary drainage (PTBD) fails. More and more emerging data not only establishes the safety of EUS-BD but also demonstrates superior efficacy over PTBD and sometimes even ERCP. Malignant gastric outlet obstruction can now be safely managed with EUS-guided gastroenterostomy. Starting from pain management in malignant tumors through celiac plexus neurolysis to various tumor ablative therapies, EUS has forged ahead over percutaneous treatment or surgical options in the management of GI malignancies. Additional data is now coming up on the prospects of EUS-guided immunotherapy and biological therapy for tumor management. The future of EUS therapeutics in the field of GI malignancies is bright. With increasing evidence, this modality becoming a key player in management of a host of complex clinical conditions arising out of GI malignancies is in the offing. This review focuses on elucidating the role of therapeutic EUS in the management of GI malignancies, a synopsis of various techniques, data on its safety and efficacy as well as future advancements in this domain.
Identifiants
pubmed: 35028906
doi: 10.1007/s12328-021-01559-4
pii: 10.1007/s12328-021-01559-4
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
11-29Informations de copyright
© 2021. Japanese Society of Gastroenterology.
Références
Mukai S, Itoi T, Baron TH, et al. Indications and techniques of biliary drainage for acute cholangitis in updated Tokyo Guidelines 2018. J Hepatobiliary Pancreat Sci. 2017;24:537–49.
pubmed: 28834389
Holt BA, Hawes R, Hasan M, et al. Biliary drainage: role of EUS guidance. Gastrointest Endosc. 2016;83:160–5.
pubmed: 26215648
Glazer ES, Hornbrook MC, Krouse RS. A meta-analysis of randomized trials: immediate stent placement vs. surgical bypass in the palliative management of malignant biliary obstruction. J Pain Symptom Manage 2014;6:307–14.
Khashab MA, Valeshabad AK, Afghani E, et al. A comparative evaluation of EUS- guided biliary drainage and percutaneous drainage in patients with distal malignant biliary obstruction and failed ERCP. Dig Dis Sci. 2015;60:557–65.
pubmed: 25081224
Nussbaum JS, Kumta NA. Endoscopic ultrasound-guided biliary drainage. Gastrointest Endosc Clin N Am. 2019;29:277–91.
pubmed: 30846153
Moole H, Dharmapuri S, Duvvuri A, et al. Endoscopic versus percutaneous biliary drainage in palliation of advanced malignant hilar obstruction: a meta-analysis and systematic review. Can J Gastroenterol Hepatol. 2016;2016:4726078.
pubmed: 27648439
pmcid: 5014937
Giovannini M, Moutardier V, Pesenti C, Bories E, Lelong B, Delpero JR. Endoscopic ultrasound-guided bilioduodenal anastomosis: a new technique for biliary drainage. Endoscopy. 2001;33:898–900.
pubmed: 11571690
Boulay BR, Lo SK. Endoscopic Ultrasound-Guided Biliary Drainage. Gastrointest Endosc Clin N Am. 2018;28:171–85.
pubmed: 29519330
Isayama H, Nakai Y, Itoi T, et al. Clinical practice guidelines for safe performance of endoscopic ultrasound/ultrasonography-guided biliary drainage: 2018. J Hepatobiliary Pancreat Sci. 2019;26:249–69.
pubmed: 31025816
pmcid: 7064894
Khan MA, Akbar A, Baron TH, et al. Endoscopic ultrasound-guided biliary drainage: a systematic review and meta-analysis. Dig Dis Sci. 2016;61:684–703.
pubmed: 26518417
Khashab MA, Valeshabad AK, Modayil R, et al. EUS-guided biliary drainage by using a standardized approach for malignant biliary obstruction: rendezvous versus direct transluminal techniques (with videos). Gastrointest Endosc. 2013;78:734–41.
pubmed: 23886353
Dhir V, Artifon EL, Gupta K, et al. Multicenter study on endoscopic ultrasound-guided expandable biliary metal stent placement: choice of access route, direction of stent insertion, and drainage route. Dig Endosc. 2014;26:430–5.
pubmed: 23941261
Kawakubo K, Isayama H, Kato H, et al. Multicenter retrospective study of endoscopic ultrasound-guided biliary drainage for malignant biliary obstruction in Japan. J Hepatobiliary Pancreat Sci. 2014;21:328–34.
pubmed: 24026963
Gupta K, Perez-Miranda M, Kahaleh M, et al. Endoscopic ultrasound-assisted bile duct access and drainage: multicenter, long-term analysis of approach, outcomes, and complications of a technique in evolution. J Clin Gastroenterol. 2014;48:80–7.
pubmed: 23632351
Dhir V, Bhandari S, Bapat M, Joshi N, Vivekanandarajah S, Maydeo A. Comparison of transhepatic and extrahepatic routes for EUS-guided rendezvous procedure for distal CBD obstruction. United European Gastroenterol J. 2013;1:103–8.
pubmed: 24917947
pmcid: 4040733
Khashab MA, Van der Merwe S, Kunda R, et al. Prospective international multicenter study on endoscopic ultrasound-guided biliary drainage for patients with malignant distal biliary obstruction after failed endoscopic retrograde cholangiopancreatography. Endosc Int Open. 2016;4:E487–96.
pubmed: 27092334
pmcid: 4831932
Tsuchiya T, Teoh AYB, Itoi T, et al. Long-term outcomes of EUS-guided choledochoduodenostomy using a lumen-apposing metal stent for malignant distal biliary obstruction: a prospective multicenter study. Gastrointest Endosc. 2018;87:1138–46.
pubmed: 28843583
Dhindsa BS, Mashiana HS, Dhaliwal A, et al. EUS-guided biliary drainage: A systematic review and meta-analysis. Endosc Ultrasound. 2020;9:101–9.
pubmed: 32295967
pmcid: 7279084
Wang K, Zhu J, Xing L, Wang Y, Jin Z, Li Z. Assessment of efficacy and safety of EUS-guided biliary drainage: a systematic review. Gastrointest Endosc. 2016;83:1218–27.
pubmed: 26542374
Han SY, Kim SO, So H, Shin E, Kim DU, Park DH. EUS-guided biliary drainage versus ERCP for first-line palliation of malignant distal biliary obstruction: a systematic review and meta-analysis. Sci Rep. 2019;9:16551.
pubmed: 31719562
pmcid: 6851119
Lee TH, Choi JH, Park do H et al. Similar Efficacies of Endoscopic Ultrasound-guided Transmural and Percutaneous Drainage for Malignant Distal Biliary Obstruction. Clin Gastroenterol Hepatol. 2016; 14:1011–19.e3.
Dhir V, Itoi T, Khashab MA, et al. Multicenter comparative evaluation of endoscopic placement of expandable metal stents for malignant distal common bile duct obstruction by ERCP or EUS-guided approach. Gastrointest Endosc. 2015;81:913–23.
pubmed: 25484326
Paik WH, Lee TH, Park DH, et al. EUS-guided biliary drainage versus ERCP for the primary palliation of malignant biliary obstruction: a multicenter randomized clinical trial. Am J Gastroenterol. 2018;113:987–97.
pubmed: 29961772
Nakai Y, Isayama H, Kawakami H, et al. Prospective multicenter study of primary EUS-guided choledochoduodenostomy using a covered metal stent. Endosc Ultrasound. 2019;8:111–7.
pubmed: 30168480
Park JK, Woo YS, Noh DH, et al. Efficacy of EUS-guided and ERCP-guided biliary drainage for malignant biliary obstruction: prospective randomized controlled study. Gastrointest Endosc. 2018;88:277–82.
pubmed: 29605722
Bang JY, Navaneethan U, Hasan M, Hawes R, Varadarajulu S. Stent placement by EUS or ERCP for primary biliary decompression in pancreatic cancer: a randomized trial (with videos). Gastrointest Endosc. 2018;88:9–17.
pubmed: 29574126
Artifon EL, Aparicio D, Paione JB, et al. Biliary drainage in patients with unresectable, malignant obstruction where ERCP fails: endoscopic ultrasonography-guided choledochoduodenostomy versus percutaneous drainage. J Clin Gastroenterol. 2012;46:768–74.
pubmed: 22810111
Bapaye A, Dubale N, Aher A. Comparison of endosonography-guided vs. percutaneous biliary stenting when papilla is inaccessible for ERCP. United European Gastroenterol J. 2013; 1:285–93.
Sharaiha RZ, Kumta NA, Desai AP, et al. Endoscopic ultrasound-guided biliary drainage versus percutaneous transhepatic biliary drainage: predictors of successful outcome in patients who fail endoscopic retrograde cholangiopancreatography. Surg Endosc. 2016;30:5500–5.
pubmed: 27129552
Sportes A, Camus M, Greget M, et al. Endoscopic ultrasound-guided hepaticogastrostomy versus percutaneous transhepatic drainage for malignant biliary obstruction after failed endoscopic retrograde cholangiopancreatography: a retrospective expertise-based study from two centers. Therap Adv Gastroenterol. 2017;10:483–93.
pubmed: 28567118
pmcid: 5424875
Park SJ, Choi JH, Park DH, et al. Expanding indication: EUS-guided hepaticoduodenostomy for isolated right intrahepatic duct obstruction (with video). Gastrointest Endosc. 2013;78:374–80.
pubmed: 23711555
Ma KW, So H, Cho DH, Oh JS, Cheung TT, Park DH. Durability and outcome of endoscopic ultrasound-guided hepaticoduodenostomy using a fully covered metal stent for segregated right intrahepatic duct dilatation. J Gastroenterol Hepatol. 2020;35:1753–60.
pubmed: 32365417
Tarantino I, Peralta M, Ligresti D, et al. Endoscopic ultrasound-guided biliary drainage of malignant stenosis, not treatable with endoscopic retrograde cholangiopancreatography: a single-center, prospective observational study. Endosc Int Open. 2021;9:E110–5.
pubmed: 33532546
pmcid: 7834702
Emmanuel J, Omar H, See LT. Endoscopic ultrasound-guided hepaticogastrostomy using a partially covered metal stent in patients with malignant biliary obstruction after failed Endoscopic retrograde cholangiopancreatography. JGH Open. 2020;4:1059–64.
pubmed: 33319037
pmcid: 7731807
Chen YI, Callichurn K, Chatterjee A et al; ELEMENT trial and for the Canadian Endoscopic Research Collaborative (CERC). ELEMENT TRIAL: study protocol for a randomized controlled trial on endoscopic ultrasound-guided biliary drainage of first intent with a lumen-apposing metal stent vs. endoscopic retrograde cholangio-pancreatography in the management of malignant distal biliary obstruction. Trials. 2019; 20:696.
Umeda J, Itoi T, Tsuchiya T, et al. A newly designed plastic stent for EUS-guided hepaticogastrostomy: a prospective preliminary feasibility study (with videos). Gastrointest Endosc. 2015;82:390-396.e2.
pubmed: 25936451
Kongkam P, Orprayoon T, Boonmee C, et al. ERCP plus endoscopic ultrasound-guided biliary drainage versus percutaneous transhepatic biliary drainage for malignant hilar biliary obstruction: a multicenter observational open-label study. Endoscopy. 2021;53:55–62.
pubmed: 32515005
Winick AB, Waybill PN, Venbrux AC. Complications of percutaneous transhepatic biliary interventions. Tech Vasc Interv Radiol. 2001;4:200–6.
pubmed: 11748558
Baron TH, Topazian MD. Endoscopic transduodenal drainage of the gallbladder: implications for endoluminal treatment of gallbladder disease. Gastrointest Endosc. 2007;65:735–7.
pubmed: 17141230
Teoh AY, Binmoeller KF, Lau JY. Single-step EUS-guided puncture and delivery of a lumen-apposing stent for gallbladder drainage using a novel cautery-tipped stent delivery system. Gastrointest Endosc. 2014;80:1171.
pubmed: 24830582
Ogura T, Nishioka N, Yamada M, Yamada T, Higuchi K. EUS-guided gallbladder drainage using an improved self-expandable covered metal stent with anti-stent migration system (with video). Dig Dis. 2021;39:150–5.
pubmed: 32512575
Podboy A, Yuan J, Stave CD, Chan SM, Hwang JH, Teoh AYB. Comparison of EUS-guided endoscopic transpapillary and percutaneous gallbladder drainage for acute cholecystitis: a systematic review with network meta-analysis. Gastrointest Endosc. 2021;93:797-804.e1.
pubmed: 32987004
Imai H, Kitano M, Omoto S, et al. EUS-guided gallbladder drainage for rescue treatment of malignant distal biliary obstruction after unsuccessful ERCP. Gastrointest Endosc. 2016;84:147–51.
pubmed: 26764194
Teoh AYB, Leung CH, Tam PTH, et al. EUS-guided gallbladder drainage versus laparoscopic cholecystectomy for acute cholecystitis: a propensity score analysis with 1-year follow-up data. Gastrointest Endosc. 2021;93:577–83.
pubmed: 32615177
Teoh AYB, Kitano M, Itoi T, et al. Endosonography-guided gallbladder drainage versus percutaneous cholecystostomy in very high-risk surgical patients with acute cholecystitis: an international randomised multicentre controlled superiority trial (DRAC 1). Gut. 2020;69:1085–91.
pubmed: 32165407
Oh D, Park DH, Song TJ, et al. Optimal biliary access point and learning curve for endoscopic ultrasound-guided hepaticogastrostomy with transmural stenting. Therap Adv Gastroenterol. 2017;10:42–53.
pubmed: 28286558
European Association for the Study of the Liver. European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018; 69:406–60.
Nguyen PT, Chang KJ. EUS in the detection of ascites and EUS-guided paracentesis. Gastrointest Endosc. 2001;54:336–9.
pubmed: 11522974
Varadarajulu S, Drelichman ER. EUS-guided therapeutic paracentesis. Gastrointest Endosc. 2008;67:758–9.
pubmed: 18178210
Lee YT, Ng EK, Hung LC, et al. Accuracy of endoscopic ultrasonography in diagnosing ascites and predicting peritoneal metastases in gastric cancer patients. Gut. 2005;54:1541–5.
pubmed: 15955787
pmcid: 1774738
DeWitt J, LeBlanc J, McHenry L, McGreevy K, Sherman S. Endoscopic ultrasound-guided fine-needle aspiration of ascites. Clin Gastroenterol Hepatol. 2007;5:609–15.
pubmed: 17336593
Chin MA. EUS-guided paracentesis and ascitic fluid analysis. Endosc Ultrasound. 2018;7:223–7.
pubmed: 30117483
pmcid: 6106149
Levy MJ, Abu Dayyeh BK, Fujii LL, et al. Detection of peritoneal carcinomatosis by EUS fine-needle aspiration: impact on staging and resectability (with videos). Gastrointest Endosc. 2015;81:1215–24.
pubmed: 25660979
Suzuki R, Irisawa A, Bhutani MS, et al. An automated spring-loaded needle for endoscopic ultrasound-guided abdominal paracentesis in cancer patients. World J Gastrointest Endosc. 2014;6:55–9.
pubmed: 24567793
pmcid: 3930891
Chang KJ, Albers CG, Nguyen P. Endoscopic ultrasound-guided fine needle aspiration of pleural and ascitic fluid. Am J Gastroenterol. 1995;90:148–50.
pubmed: 7801920
Kaushik N, Khalid A, Brody D, McGrath K. EUS-guided paracentesis for the diagnosis of malignant ascites. Gastrointest Endosc. 2006;64:908–13.
pubmed: 17140897
Köck R, Jürgensen C, Fischer-Lampsatis R. Endosonography-guided drainage of loculated malignant ascites using double-pigtail plastic stents. Endosc Int Open. 2018;6:E902–6.
pubmed: 29978013
pmcid: 6032637
Romero-Castro R, Jimenez-Garcia VA, Boceta-Osuna J, et al. Endoscopic ultrasound-guided placement of plastic pigtail stents for the drainage of refractory malignant ascites. Endosc Int Open. 2017;5:E1096–9.
pubmed: 29250586
pmcid: 5659864
Romero-Castro R. EUS guided drainage of refractory malignant ascites. [accessed 2021 Mar 1]. In: ClinicalTrials.gov [Internet]. Bethesda (MD): U.S. National Library of Medicine. Available from: https://clinicaltrials.gov/ct2/show/NCT03550560 . ClinicalTrials.gov Identifier: NCT03550560
Wardeh R, Lee JG, Gu M. Endoscopic ultrasound-guided paracentesis of ascitic fluid: a morphologic study with ultrasonographic correlation. Cancer Cytopathol. 2011;119:27–36.
pubmed: 21072835
DiMaio CJ, Nagula S, Goodman KA, et al. EUS-guided fiducial placement for image-guided radiation therapy in GI malignancies by using a 22-gauge needle (with videos). Gastrointest Endosc. 2010;71:1204–10.
pubmed: 20598247
Varadarajulu S, Trevino JM, Shen S, Jacob R. The use of endoscopic ultrasound-guided gold markers in image-guided radiation therapy of pancreatic cancers: a case series. Endoscopy. 2010;42:423–5.
pubmed: 20232282
Pishvaian AC, Collins B, Gagnon G, Ahlawat S, Haddad NG. EUS-guided fiducial placement for CyberKnife radiotherapy of mediastinal and abdominal malignancies. Gastrointest Endosc. 2006;64:412–7.
pubmed: 16923491
Choi JH, Seo DW, Park DH, Lee SK, Kim MH. Fiducial placement for stereotactic body radiation therapy under only endoscopic ultrasonography guidance in pancreatic and hepatic malignancy: practical feasibility and safety. Gut Liver. 2014;8:88–93.
pubmed: 24516706
Jeurnink SM, Steyerberg EW, van Hooft JE et al; Dutch SUSTENT Study Group. Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial. Gastrointest Endosc. 2010; 71:490–9.
Amin S, Sethi A. Endoscopic Ultrasound-Guided Gastrojejunostomy. Gastrointest Endosc Clin N Am. 2017;27:707–13.
pubmed: 28918806
Dawod E, Nieto JM. Endoscopic ultrasound guided gastrojejunostomy. Transl Gastroenterol Hepatol. 2018;3:93.
pubmed: 30603729
pmcid: 6286920
Itoi T, Ishii K, Ikeuchi N, et al. Prospective evaluation of endoscopic ultrasonography-guided double-balloon-occluded gastrojejunostomy bypass (EPASS) for malignant gastric outlet obstruction. Gut. 2016;65:193–5.
pubmed: 26282674
Chen YI, Itoi T, Baron TH, et al. EUS-guided gastroenterostomy is comparable to enteral stenting with fewer re-interventions in malignant gastric outlet obstruction. Surg Endosc. 2017;31:2946–52.
pubmed: 27834024
Chandan S, Khan SR, Mohan BP, et al. EUS-guided gastroenterostomy versus enteral stenting for gastric outlet obstruction: Systematic review and meta-analysis. Endosc Int Open. 2021;9:E496–504.
pubmed: 33655056
pmcid: 7899789
Khashab MA, Bukhari M, Baron TH, et al. International multicenter comparative trial of endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for the treatment of malignant gastric outlet obstruction. Endosc Int Open. 2017;5:E275–81.
pubmed: 28382326
pmcid: 5378550
Marino A, Bessissow A, Miller C et al. Modified endoscopic ultrasound-guided double-balloon-occluded gastroenterostomy bypass (M-EPASS): a pilot study. Endoscopy. 2021 Feb 16. doi: https://doi.org/10.1055/a-1392-4546 . Epub ahead of print. PMID: 33592629.
Nguyen NQ, Hamerski CM, Nett A et al. 1033 EUS guided gastrojejunostomy (EUS-GJ) using a nasobiliary tube (NBT) for water infusion. Gastrointestinal Endoscopy. 2020;91:AB93.
Jovani M, Ichkhanian Y, Parsa N, et al. Assessment of the learning curve for EUS-guided gastroenterostomy for a single operator. Gastrointest Endosc. 2021;93:1088–93.
pubmed: 32991868
Bowles MJ, Benjamin IS. ABC of the upper gastrointestinal tract: Cancer of the stomach and pancreas. BMJ. 2001;323:1413–6.
pubmed: 11744568
pmcid: 1121865
Yang J, Bauer BA, Wahner-Roedler DL, Chon TY, Xiao L. The modified WHO analgesic ladder: is it appropriate for chronic non-cancer pain? J Pain Res. 2020;13:411–7.
pubmed: 32110089
pmcid: 7038776
Faigel DO, Veloso KM, Long WB, Kochman ML. Endosonography-guided celiac plexus injection for abdominal pain due to chronic pancreatitis. Am J Gastroenterol. 1996;91:1675.
pubmed: 8759702
Wiersema MJ, Wiersema LM. Endosonography-guided celiac plexus neurolysis. Gastrointest Endosc. 1996;44:656–62.
pubmed: 8979053
Wyse JM, Battat R, Sun S, et al. Practice guidelines for endoscopic ultrasound-guided celiac plexus neurolysis. Endosc Ultrasound. 2017;6:369–75.
pubmed: 29251270
pmcid: 5752758
Wyse JM, Carone M, Paquin SC, Usatii M, Sahai AV. Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer. J Clin Oncol. 2011;29:3541–6.
pubmed: 21844506
Fujii-Lau LL, Bamlet WR, Eldrige JS, et al. Impact of celiac neurolysis on survival in patients with pancreatic cancer. Gastrointest Endosc. 2015;82:46-56.e2.
pubmed: 25800661
pmcid: 6017988
Alvarez-Sánchez MV, Jenssen C, Faiss S, Napoléon B. Interventional endoscopic ultrasonography: an overview of safety and complications. Surg Endosc. 2014;28:712–34.
pubmed: 24196551
Bang JY, Sutton B, Hawes RH, Varadarajulu S. EUS-guided celiac ganglion radiofrequency ablation versus celiac plexus neurolysis for palliation of pain in pancreatic cancer: a randomized controlled trial (with videos). Gastrointest Endosc. 2019; 89:58–66. e3.
Rai P, Cr L, Kc H. Endoscopic ultrasound-guided celiac plexus neurolysis improves pain in gallbladder cancer. Indian J Gastroenterol. 2020;39:171–5.
pubmed: 32065352
Wang KX, Jin ZD, Du YQ, et al. EUS-guided celiac ganglion irradiation with iodine-125 seeds for pain control in pancreatic carcinoma: a prospective pilot study. Gastrointest Endosc. 2012;76:945–52.
pubmed: 22841501
Zhao Y, Guo X, Wang K, et al. A retrospective multicenter study comparing bupivacaine and ropivacaine in endoscopic ultrasound guided celiac plexus neurolysis. Ann Palliat Med. 2021;10:1755–62.
pubmed: 33302641
Saleh AAG, Sultan A, Hammouda MA, Shawki A, El Ghaffar MA. Value of adding dexmedetomidine in endoscopic ultrasound-guided celiac plexus neurolysis for treatment of pancreatic cancer-associated pain. J Gastrointest Cancer. 2021;52:682–9.
pubmed: 32621112
Chang KJ, Nguyen PT, Thompson JA, et al. Phase I clinical trial of allogeneic mixed lymphocyte culture (cytoimplant) delivered by endoscopic ultrasound-guided fine-needle injection in patients with advanced pancreatic carcinoma. Cancer. 2000;88:1325–35.
pubmed: 10717613
Irisawa A, Takagi T, Kanazawa M, et al. Endoscopic ultrasound-guided fine-needle injection of immature dendritic cells into advanced pancreatic cancer refractory to gemcitabine: a pilot study. Pancreas. 2007;35:189–90.
pubmed: 17632329
Hirooka Y, Itoh A, Kawashima H, et al. A combination therapy of gemcitabine with immunotherapy for patients with inoperable locally advanced pancreatic cancer. Pancreas. 2009;38:e69-74.
pubmed: 19276867
Hanna N, Ohana P, Konikoff FM, et al. Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer. Cancer Gene Ther. 2012;19:374–81.
pubmed: 22498722
Hecht JR, Bedford R, Abbruzzese JL, et al. A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin Cancer Res. 2003;9:555–61.
pubmed: 12576418
Hirooka Y, Kasuya H, Ishikawa T, et al. A Phase I clinical trial of EUS-guided intratumoral injection of the oncolytic virus, HF10 for unresectable locally advanced pancreatic cancer. BMC Cancer. 2018;18:596.
pubmed: 29801474
pmcid: 5970460
Hecht JR, Farrell JJ, Senzer N, et al. EUS or percutaneously guided intratumoral TNFerade biologic with 5-fluorouracil and radiotherapy for first-line treatment of locally advanced pancreatic cancer: a phase I/II study. Gastrointest Endosc. 2012;75:332–8.
pubmed: 22248601
pmcid: 4380192
Levy MJ, Alberts SR, Bamlet WR, et al. EUS-guided fine-needle injection of gemcitabine for locally advanced and metastatic pancreatic cancer. Gastrointest Endosc. 2017;86:161–9.
pubmed: 27889543
Nishimura M, Matsukawa M, Fujii Y, et al. Effects of EUS-guided intratumoral injection of oligonucleotide STNM01 on tumor growth, histology, and overall survival in patients with unresectable pancreatic cancer. Gastrointest Endosc. 2018;87:1126–31.
pubmed: 29122598
Sun S, Xu H, Xin J, Liu J, Guo Q, Li S. Endoscopic ultrasound-guided interstitial brachytherapy of unresectable pancreatic cancer: results of a pilot trial. Endoscopy. 2006;38:399–403.
pubmed: 16680642
Jin Z, Du Y, Li Z, Jiang Y, Chen J, Liu Y. Endoscopic ultrasonography-guided interstitial implantation of iodine 125-seeds combined with chemotherapy in the treatment of unresectable pancreatic carcinoma: a prospective pilot study. Endoscopy. 2008;40:314–20.
pubmed: 18283622
Du Y, Jin Z, Meng H, et al. Long-term effect of gemcitabine-combined endoscopic ultrasonography-guided brachytherapy in pancreatic cancer. J Interv Gastroenterol. 2013;3:18–24.
Bhutani MS, Cazacu IM, Luzuriaga Chavez AA, et al. Novel EUS-guided brachytherapy treatment of pancreatic cancer with phosphorus-32 microparticles: first United States experience. VideoGIE. 2019;4:223–5.
pubmed: 31065616
pmcid: 6495077
Arcidiacono PG, Carrara S, Reni M, et al. Feasibility and safety of EUS-guided cryothermal ablation in patients with locally advanced pancreatic cancer. Gastrointest Endosc. 2012;76:1142–51.
pubmed: 23021160
Petrone MC, Testoni SG, Cava M, et al. Endoscopic ultrasound guided HybridTherm ablation in patients with stage III pancreatic ductal adenocarcinoma: Prospective single center cohort study. United European Gastroenterol J. 2017;3:A377.
Choi JH, Oh D, Lee JH, et al. Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter. Endoscopy. 2015;47:1035–8.
pubmed: 26070006
DeWitt JM, Sandrasegaran K, O’Neil B, et al. Phase 1 study of EUS-guided photodynamic therapy for locally advanced pancreatic cancer. Gastrointest Endosc. 2019;89:390–8.
pubmed: 30222972
Hanada Y, Pereira SP, Pogue B, et al. EUS-guided verteporfin photodynamic therapy for pancreatic cancer. Gastrointest Endosc. 2021;94:179–86.
pubmed: 33647286
Di Matteo F, Picconi F, Martino M et al. Endoscopic ultrasound-guided Nd:YAG laser ablation of recurrent pancreatic neuroendocrine tumor: a promising revolution? Endoscopy. 2014;46 Suppl 1 UCTN: E380–1
Matthes K, Mino-Kenudson M, Sahani DV, et al. EUS-guided injection of paclitaxel (OncoGel) provides therapeutic drug concentrations in the porcine pancreas (with video). Gastrointest Endosc. 2007;65:448–53.
pubmed: 17173909
Karaca C, Cizginer S, Konuk Y, et al. Feasibility of EUS-guided injection of irinotecan-loaded microspheres into the swine pancreas. Gastrointest Endosc. 2011;73:603–6.
pubmed: 21238959
Sun S, Qingjie L, Qiyong G, Mengchun W, Bo Q, Hong X. EUS-guided interstitial brachytherapy of the pancreas: a feasibility study. Gastrointest Endosc. 2005;62:775–9.
pubmed: 16246695
Dhaliwal A, Kolli S, Dhindsa BS, et al. Efficacy of EUS-RFA in pancreatic tumors: Is it ready for prime time? A systematic review and meta-analysis. Endosc Int Open. 2020;8:E1243–51.
pubmed: 33015325
pmcid: 7508651
Li T, Khokhlova T, Maloney E, et al. Endoscopic high-intensity focused US: technical aspects and studies in an in vivo porcine model (with video). Gastrointest Endosc. 2015;81:1243–50.
pubmed: 25759124
pmcid: 4452137