Enantioselective Deaminative Alkylation of Amino Acid Derivatives with Unactivated Olefins.

Alkenes

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
26 01 2022
Historique:
pubmed: 15 1 2022
medline: 3 3 2022
entrez: 14 1 2022
Statut: ppublish

Résumé

Herein, we report the first Ni-catalyzed enantioselective deaminative alkylation of amino acid and peptide derivatives with unactivated olefins. Key for success was the discovery of a new sterically encumbered bis(oxazoline) ligand backbone, thus offering a de novo technology for accessing enantioenriched

Identifiants

DOI: 10.1021/jacs.1c12350 PMID: 35029378
pubmed: 35029378
doi: 10.1021/jacs.1c12350
doi:

Substances chimiques

Alkenes 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1130-1137

Auteurs

Shang-Zheng Sun (SZ)

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain.

Yue-Ming Cai (YM)

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

De-Liang Zhang (DL)

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

Jia-Bao Wang (JB)

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

Hong-Qing Yao (HQ)

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

Xi-Yan Rui (XY)

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

Ruben Martin (R)

Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007 Tarragona, Spain.
ICREA, Passeig Lluís Companys, 23, 08010, Barcelona, Spain.
ORCID: 0000-0002-2543-0221

Ming Shang (M)

Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
ORCID: 0000-0002-0785-8427

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcènes › Enantioselective Deaminative Alkylation of...