Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis.

Animals Circadian Clocks Circadian Rhythm Homeostasis Liver / metabolism Metabolomics Mice Physical Conditioning, Animal
2-hydroxybutyrate arteriovenous metabolomics circadian rhythms exercise metabolism exerkines metabolomics multitissue analysis

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
01 02 2022
Historique:
received: 29 09 2020
revised: 22 11 2021
accepted: 15 12 2021
pubmed: 15 1 2022
medline: 8 4 2022
entrez: 14 1 2022
Statut: ppublish

Résumé

Tissue sensitivity and response to exercise vary according to the time of day and alignment of circadian clocks, but the optimal exercise time to elicit a desired metabolic outcome is not fully defined. To understand how tissues independently and collectively respond to timed exercise, we applied a systems biology approach. We mapped and compared global metabolite responses of seven different mouse tissues and serum after an acute exercise bout performed at different times of the day. Comparative analyses of intra- and inter-tissue metabolite dynamics, including temporal profiling and blood sampling across liver and hindlimb muscles, uncovered an unbiased view of local and systemic metabolic responses to exercise unique to time of day. This comprehensive atlas of exercise metabolism provides clarity and physiological context regarding the production and distribution of canonical and novel time-dependent exerkine metabolites, such as 2-hydroxybutyrate (2-HB), and reveals insight into the health-promoting benefits of exercise on metabolism.

Identifiants

DOI: 10.1016/j.cmet.2021.12.016 PMID: 35030324
pubmed: 35030324
pii: S1550-4131(21)00635-5
doi: 10.1016/j.cmet.2021.12.016
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

329-345.e8

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests J.R.Z. is an Advisory Board member for Cell Metabolism. The authors declare no competing interests.

Auteurs

Shogo Sato (S)

Center for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.

Kenneth A Dyar (KA)

Metabolic Physiology, Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; German Center for Diabetes Research, Neuherberg, Germany.

Jonas T Treebak (JT)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Sara L Jepsen (SL)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.

Amy M Ehrlich (AM)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Stephen P Ashcroft (SP)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Kajetan Trost (K)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Thomas Kunzke (T)

Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Verena M Prade (VM)

Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Lewin Small (L)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Astrid Linde Basse (AL)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Milena Schönke (M)

Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.

Siwei Chen (S)

Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA, USA.

Muntaha Samad (M)

Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA, USA.

Pierre Baldi (P)

Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA, USA.

Romain Barrès (R)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Axel Walch (A)

Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Thomas Moritz (T)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Jens J Holst (JJ)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark.

Dominik Lutter (D)

German Center for Diabetes Research, Neuherberg, Germany; Computational Discovery Research, Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Electronic address: dominik.lutter@helmholtz-muenchen.de.

Juleen R Zierath (JR)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Molecular Medicine and Surgery, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden; Department of Physiology and Pharmacology, Integrative Physiology, Karolinska Institutet, Stockholm, Sweden. Electronic address: juleen.zierath@ki.se.

Paolo Sassone-Corsi (P)

Center for Epigenetics and Metabolism, INSERM U1233, Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA, USA.

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Classifications MeSH

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