Periodontitis predicts HbA1c levels and glucose variability in type 1 diabetic patients: the PARODIA Florence Project study.
Glucose variability
Glycated hemoglobin
Periodontitis
Type 1 diabetes
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
15
10
2021
accepted:
29
11
2021
pubmed:
16
1
2022
medline:
7
4
2022
entrez:
15
1
2022
Statut:
ppublish
Résumé
The aim of the present study was to assess the extent and severity of periodontal disease among type 1 diabetic patients (T1DM) and to investigate the possible association with systemic markers of glucose control and variability. Patients were consecutively enrolled in a Diabetic Unit. A full-mouth periodontal evaluation was performed, and data on systemic markers of diabetes were collected. Descriptive statistics and logistic and linear models were performed. A total of 136 T1DM patients (mean age: 45.5 ± 14.6 years) were examined. Periodontitis was detected in 62% of cases (mean CAL: 3.0 ± 0.9 mm): stage III periodontitis was diagnosed in 32% of patients while stage IV in 8%. Mean level of glycated hemoglobin (HbA1c) was 7.5% ± 1.4. Among the investigated factors, mean CAL (p=0.040) was associated with HbA1c ≥ 7%; 93% of patients with mean CAL > 6 mm showed HbA1c ≥ 7%. Mean CAL (p=0.004), mean PPD (p=0.005), mean FMPS (p=0.030), and stage III/IV periodontitis (p=0.018) predict glucose coefficient of variation (CV). Periodontitis showed a relevant prevalence in the present, well-controlled T1DM population and predicts poor glycemic control (HbA1c ≥7%) and higher glucose variability. The present findings suggest that periodontal infection may have systemic effects also in T1DM patients. The extent and severity of periodontitis and its possible systemic effects in T1DM patients could be underestimated.
Identifiants
pubmed: 35031877
doi: 10.1007/s00784-021-04326-4
pii: 10.1007/s00784-021-04326-4
doi:
Substances chimiques
Blood Glucose
0
Glycated Hemoglobin A
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Langues
eng
Pagination
3585-3591Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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