Baseline fat fraction is a strong predictor of disease progression in Becker muscular dystrophy.


Journal

NMR in biomedicine
ISSN: 1099-1492
Titre abrégé: NMR Biomed
Pays: England
ID NLM: 8915233

Informations de publication

Date de publication:
07 2022
Historique:
revised: 24 12 2021
received: 24 08 2021
accepted: 10 01 2022
pubmed: 16 1 2022
medline: 18 6 2022
entrez: 15 1 2022
Statut: ppublish

Résumé

In Becker muscular dystrophy (BMD), muscle weakness progresses relatively slowly, with a highly variable rate among patients. This complicates clinical trials, as clinically relevant changes are difficult to capture within the typical duration of a trial. Therefore, predictors for disease progression are needed. We assessed if temporal increase of fat fraction (FF) in BMD follows a sigmoidal trajectory and whether fat fraction at baseline (FFbase) could therefore predict FF increase after 2 years (ΔFF). Thereafter, for two different MR-based parameters, we tested the additional predictive value to FFbase. We used 3-T Dixon data from the upper and lower leg, and multiecho spin-echo MRI and 7-T

Identifiants

pubmed: 35032073
doi: 10.1002/nbm.4691
pmc: PMC9286612
doi:

Substances chimiques

Adenosine Triphosphate 8L70Q75FXE

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e4691

Informations de copyright

© 2022 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

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Auteurs

Thom T J Veeger (TTJ)

C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

Nienke M van de Velde (NM)

Department of Neurology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Duchenne Center Netherlands, The Netherlands.

Kevin R Keene (KR)

Department of Neurology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

Erik H Niks (EH)

Department of Neurology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Duchenne Center Netherlands, The Netherlands.

Melissa T Hooijmans (MT)

Department of Radiology & Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Andrew G Webb (AG)

C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

Jurriaan H de Groot (JH)

Department of Rehabilitation Medicine, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

Hermien E Kan (HE)

C. J. Gorter Center for High Field MRI, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.
Duchenne Center Netherlands, The Netherlands.

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