Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.
Animals
Autophagy
/ drug effects
Autophagy-Related Protein 5
/ metabolism
Crohn Disease
/ pathology
Dextran Sulfate
Disease Progression
Disease Susceptibility
Humans
Inflammation
/ pathology
Intestines
/ pathology
Macrophages
/ drug effects
Mice, Inbred C57BL
Nickel
/ toxicity
THP-1 Cells
Tumor Necrosis Factor alpha-Induced Protein 3
/ metabolism
A20/TNFAIP3
Autophagy
Crohn's disease
Macrophage
Nickel
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
12 02 2022
12 02 2022
Historique:
received:
22
12
2021
accepted:
28
12
2021
pubmed:
16
1
2022
medline:
11
2
2022
entrez:
15
1
2022
Statut:
ppublish
Résumé
Crohn's disease is an inflammatory disease of the gut caused by a complex interplay among genetic, microbial, and environmental factors. The intestinal tract is constantly exposed to metals and other trace elements ingested as food. Synchrotron radiation-induced X-ray fluorescence spectroscopy and X-ray absorption fine structure analysis revealed the deposition of nickel particles within Crohn's disease tissue specimens. After nickel particle stimulation, THP-1 cells showed filopodia formation and autophagic vacuoles containing lipid bodies. Nickel particles precipitated colitis in mice bearing mutations of the IBD susceptibility protein A20/TNFAIP3. Nickel particles also exacerbated dextran sulfate sodium-induced colitis in mice harboring myeloid cell-specific Atg5 deficiency. These findings illustrate that nickel particle ingestion may worsen Crohn's disease by perturbing autophagic processes in the intestine, providing new insights into environmental factors in Crohn's disease pathogenesis.
Identifiants
pubmed: 35032835
pii: S0006-291X(21)01762-9
doi: 10.1016/j.bbrc.2021.12.111
pii:
doi:
Substances chimiques
Autophagy-Related Protein 5
0
Nickel
7OV03QG267
Dextran Sulfate
9042-14-2
Tumor Necrosis Factor alpha-Induced Protein 3
EC 3.4.19.12
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
74-80Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.