Translating osteoarthritis genetics research: challenging times ahead.
development
genetics
osteoarthritis
translation
treatments
Journal
Trends in molecular medicine
ISSN: 1471-499X
Titre abrégé: Trends Mol Med
Pays: England
ID NLM: 100966035
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
23
11
2021
revised:
21
12
2021
accepted:
21
12
2021
pubmed:
17
1
2022
medline:
2
4
2022
entrez:
16
1
2022
Statut:
ppublish
Résumé
The ultimate goal of molecular genetic studies of human diseases is to translate the discoveries for patient benefit. For diseases that lack licensed disease-modifying therapeutics, such as osteoarthritis (OA), the need is acute. OA is polygenic and affects older individuals, with a recent genome-wide study of over 800 000 individuals adding 52 novel association signals to those already reported on for this common arthritis. Many of the predicted effector genes of these signals encode proteins that are targets of drugs for other indications, highlighting repurposing opportunities. Here, the potential for OA genetic data to translate is discussed, including whether the developmental origin of OA will limit the application of genetic risk data for disease-modification purposes.
Identifiants
pubmed: 35033441
pii: S1471-4914(21)00324-5
doi: 10.1016/j.molmed.2021.12.007
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
176-182Subventions
Organisme : Versus Arthritis
ID : 20771
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P020941/1
Pays : United Kingdom
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.