Reward Processing in Children With Psychotic-Like Experiences.
childhood
fMRI
psychotic-like experiences
Journal
Schizophrenia bulletin open
ISSN: 2632-7899
Titre abrégé: Schizophr Bull Open
Pays: United States
ID NLM: 101770329
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
entrez:
17
1
2022
pubmed:
18
1
2022
medline:
18
1
2022
Statut:
epublish
Résumé
Alterations to striatal reward pathways have been identified in individuals with psychosis. They are hypothesized to be a key mechanism that generate psychotic symptoms through the production of aberrant attribution of motivational salience and are proposed to result from accumulated childhood adversity and genetic risk, making the striatal system hyper-responsive to stress. However, few studies have examined whether children with psychotic-like experiences (PLEs) also exhibit these alterations, limiting our understanding of how differences in reward processing relate to hallucinations and delusional ideation in childhood. Consequently, we examined whether PLEs and PLE-related distress were associated with reward-related activation in the nucleus accumbens (NAcc). The sample consisted of children (
Identifiants
pubmed: 35036918
doi: 10.1093/schizbullopen/sgab054
pii: sgab054
pmc: PMC8756103
doi:
Types de publication
Journal Article
Langues
eng
Pagination
sgab054Subventions
Organisme : Medical Research Council
ID : G0901310
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S006613/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center.
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