Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork-A review.
extracellular matrix
glaucoma
trabecular meshwork
Journal
Clinical & experimental ophthalmology
ISSN: 1442-9071
Titre abrégé: Clin Exp Ophthalmol
Pays: Australia
ID NLM: 100896531
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
19
11
2021
received:
30
08
2021
accepted:
26
11
2021
pubmed:
18
1
2022
medline:
6
5
2022
entrez:
17
1
2022
Statut:
ppublish
Résumé
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of the eye. It does this by establishing a tunable outflow resistance, defined by the interplay between cells and their extracellular matrix (ECM) milieu, and the molecular interactions between ECM proteins. During normal tissue homeostasis, the ECM is remodelled and trabecular cell behaviour is modified, permitting increased aqueous fluid outflow to maintain intraocular pressure (IOP) within a relatively narrow physiological pressure. Dysfunction in the normal homeostatic process leads to increased outflow resistance and elevated IOP, which is a primary risk factor for glaucoma. This review delineates some of the changes in the ECM that lead to gross as well as some more subtle changes in the structure and function of the ECM, and their impact on trabecular cell behaviour. These changes are discussed in the context of outflow resistance and glaucoma.
Identifiants
pubmed: 35037377
doi: 10.1111/ceo.14027
pmc: PMC9199435
mid: NIHMS1812415
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
163-182Subventions
Organisme : NEI NIH HHS
ID : P30 EY016665
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY010572
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY017006
Pays : United States
Organisme : Research to Prevent Blindness
Organisme : NIH/NEI
ID : EY017006
Organisme : NEI NIH HHS
ID : R01 EY019643
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY032905
Pays : United States
Informations de copyright
© 2022 Royal Australian and New Zealand College of Ophthalmologists.
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