Blocking of VEGF-A is not sufficient to completely revert its long-term effects on the barrier formed by retinal endothelial cells.
Angiogenesis Inhibitors
/ therapeutic use
Animals
Antibodies, Monoclonal, Humanized
/ therapeutic use
Biological Transport
Blotting, Western
Cattle
Cell Movement
/ drug effects
Cells, Cultured
Claudin-1
/ metabolism
Claudin-5
/ metabolism
Electrophoresis, Polyacrylamide Gel
Endothelial Cells
/ drug effects
Enzyme-Linked Immunosorbent Assay
Humans
Peptide Fragments
/ antagonists & inhibitors
Ranibizumab
/ therapeutic use
Retinal Vessels
/ cytology
Tight Junctions
/ drug effects
Vascular Endothelial Growth Factor A
/ antagonists & inhibitors
Aflibercept
Barrier stability
Brolucizumab
Cell adhesion
Paracellular flow
Plasmalemma vesicle-associated protein
Ranibizumab
Retinal endothelial cells
Tight junction
Transcellular flow
Transcytosis
VEGF-A
Journal
Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
07
09
2021
revised:
20
12
2021
accepted:
10
01
2022
pubmed:
18
1
2022
medline:
5
3
2022
entrez:
17
1
2022
Statut:
ppublish
Résumé
The VEGF-A-induced functional impairment of the barrier formed by retinal endothelial cells (REC) can be prevented and even - at least temporarily - reverted by trapping the growth factor in a complex with a VEGF-binding protein or by inhibiting the activity of the VEGF receptor 2 (VEGFR2). In an approach to emulate the clinically relevant situation of constant exposure to effectors, we investigated (1) whether prolonged exposure to VEGF-A
Identifiants
pubmed: 35038456
pii: S0014-4835(22)00026-4
doi: 10.1016/j.exer.2022.108945
pii:
doi:
Substances chimiques
Angiogenesis Inhibitors
0
Antibodies, Monoclonal, Humanized
0
Claudin-1
0
Claudin-5
0
Peptide Fragments
0
Vascular Endothelial Growth Factor A
0
vascular endothelial growth factor A (138-165)
0
brolucizumab
XSZ53G39H5
Ranibizumab
ZL1R02VT79
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
108945Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.