The Eastern Cooperative Oncology Group Performance Status as a prognostic factor of stage I-III colorectal cancer surgery for elderly patients: a multi-institutional retrospective analysis.
Colorectal cancer
Eastern Cooperative Oncology Group Performance Status
Elderly
Prognosis
Surgery
Journal
Surgery today
ISSN: 1436-2813
Titre abrégé: Surg Today
Pays: Japan
ID NLM: 9204360
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
14
06
2021
accepted:
24
10
2021
pubmed:
19
1
2022
medline:
28
6
2022
entrez:
18
1
2022
Statut:
ppublish
Résumé
The relationship between the general condition and long-term prognosis in elderly patients with colorectal cancer (CRC) undergoing curative surgery remains unclear. This study investigated the risk factors for poor long-term outcomes in elderly patients with CRC. Data of pStage I to III patients with CRC ≥ 80 years old who underwent curative surgery were collected from a multi-institutional database of the Japanese study group for postoperative follow-up of CRC. We retrospectively investigated the poor prognostic factors for the overall survival (OS) and relapse-free survival (RFS). A total of 473 patients with a median age of 83 years were investigated (315, 121, 34, and 3 with an Eastern Cooperative Oncology Group Performance Status [ECOG-PS] 0, 1, 2, and 3, respectively). Multivariate Cox regression analysis showed that ECOG-PS ≥ 2 and positive lymph node metastasis were independently associated with a poor OS (both p < 0.01). Positive lymph node metastasis (p < 0.01) and tumor depth (T3 or T4) (p = 0.02) were independently associated with a poor RFS. In Stages I and II, but not Stage III patients, the OS was significantly worse in those with ECOG-PS ≥ 2 than in those with ECOG-PS ≤ 1. Preoperative ECOG-PS was a significant prognostic factor for elderly patients with CRC after curative surgery.
Identifiants
pubmed: 35039939
doi: 10.1007/s00595-021-02412-4
pii: 10.1007/s00595-021-02412-4
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1081-1089Informations de copyright
© 2021. The Author(s) under exclusive licence to Springer Nature Singapore Pte Ltd.
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