Histopathological evaluation of insulin-DMSO formula designed for direct nose-to-brain delivery.
Journal
Histology and histopathology
ISSN: 1699-5848
Titre abrégé: Histol Histopathol
Pays: Spain
ID NLM: 8609357
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
pubmed:
19
1
2022
medline:
25
6
2022
entrez:
18
1
2022
Statut:
ppublish
Résumé
The combination of insulin and DMSO is a patented (Publication No US8987199B2), noninvasive, pharmaceutically strategized preparation for direct nose-to-brain delivery (DN2BD) suggested for the treatment of Alzheimer's disease (AD). Although its main ingredients have been individually researched, no histopathological investigations have been conducted to address this combination effect on the CNS and nasal tissues in animals. The present work was, therefore, designed to investigate the potential histopathological changes induced by this new pharmaceutical combination using a newly developed refractory staining method. The findings presented herein showed no signs of treatment-related lesions or behavioral changes in Sprague Dawley rats following a three-month successive treatment with two strengths of the formula.
Identifiants
pubmed: 35040114
pii: HH-18-421
doi: 10.14670/HH-18-421
doi:
Substances chimiques
Insulin
0
Dimethyl Sulfoxide
YOW8V9698H
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
431-439Références
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