Quantifying neonatal patient effort using non-invasive model-based methods.
Intensive care unit
Lung
Neonatal
Physiology
Respiratory system
Journal
Medical & biological engineering & computing
ISSN: 1741-0444
Titre abrégé: Med Biol Eng Comput
Pays: United States
ID NLM: 7704869
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
08
04
2021
accepted:
15
12
2021
pubmed:
20
1
2022
medline:
22
2
2022
entrez:
19
1
2022
Statut:
ppublish
Résumé
Patient-specific spontaneous breathing effort (SB) is common in invasively mechanically ventilated (MV) adult patients, and especially common in preterm neonates who are not typically sedated. However, there is no proven, ethically feasible and non-invasive method to quantify SB effort in neonates, creating the potential for model-based measures. Lung mechanics and SB effort are segregated using a basis function model to identify passive lung mechanics, and an additional time-varying elastance model to identify patient-specific SB effort and asynchrony as negative and positive added elastances, respectively. Data from ten preterm neonates on standard MV care in the neonatal intensive care unit (NICU) are used to assess this model-based approach, using area under the curve (AUC) for positive (asynchrony) and negative (SB effort) time-varying elastance. Median [interquartile-range (IQR)] of passive pulmonary lung elastance was 3.82 [2.09-5.80] cmH
Identifiants
pubmed: 35043368
doi: 10.1007/s11517-021-02491-y
pii: 10.1007/s11517-021-02491-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
739-751Informations de copyright
© 2021. International Federation for Medical and Biological Engineering.
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