Treatment outcomes with purine nucleoside analog alone or with rituximab for hairy cell leukemia at first relapse.
hairy cell leukemia
purine nucleoside analog
rituximab
Journal
European journal of haematology
ISSN: 1600-0609
Titre abrégé: Eur J Haematol
Pays: England
ID NLM: 8703985
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
revised:
04
01
2022
received:
23
09
2021
accepted:
10
01
2022
pubmed:
20
1
2022
medline:
23
4
2022
entrez:
19
1
2022
Statut:
ppublish
Résumé
Frontline treatment of hairy cell leukemia (HCL) with a single course of the purine nucleoside analog (PNA) produces a high rate of complete remission (CR) with prolonged durations. At the time of relapse, although treatment guidelines recommend re-treatment with a PNA alone or in combination with rituximab (R), practice patterns vary and data supporting each approach are limited. We conducted a multisite outcomes analysis of patients treated for HCL between 1995 and 2018 at six US medical centers. All patients were treated with frontline PNA and subsequently required treatment with a PNA alone (PNA) or with R (+R). Of the 88 patients analyzed, 56 (63.6%) received second-line PNA and 22 (36.4%) received a PNA + R. Baseline characteristics of both groups were similar. There was no difference in median PFS [67 months (95% CI 43.8 non-reached (NR)) vs. 65 months (95% CI 60-NR)] or 5-year OS [98% (95% CI 0.94-1) vs. 94% (95% CI 0.83-1), p = .104] in the PNA versus PNA + R cohorts, respectively. To our knowledge, this is the largest study evaluating the role of R in treatment of relapsed HCL and suggests that there is no advantage to the addition of R to PNA therapy at the time of first re-treatment.
Substances chimiques
Nucleosides
0
Purine Nucleosides
0
Purines
0
Rituximab
4F4X42SYQ6
purine
W60KTZ3IZY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-382Informations de copyright
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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