Correlations between cerebrospinal fluid biomarkers, neurocognitive tests, and resting-state electroencephalography (rsEEG) in patients with HIV-associated neurocognitive disorders.
CSF biomarkers
EEG
HAND
HIV
Neopterin
Neurocognitive disorders
Journal
Journal of neurovirology
ISSN: 1538-2443
Titre abrégé: J Neurovirol
Pays: United States
ID NLM: 9508123
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
received:
28
03
2021
accepted:
18
12
2021
revised:
05
11
2021
pubmed:
20
1
2022
medline:
15
6
2022
entrez:
19
1
2022
Statut:
ppublish
Résumé
HIV-associated neurocognitive disorders (HAND) are highly prevalent in people living with HIV (PLWH) despite successful treatment with combination antiretroviral therapy (cART). HAND pathogenesis is complex and definitive surrogate biomarkers are not clearly defined. Brain function has been assessed through the evaluation of cortical source rhythms with delta waves associated with neurological impairment. The aim of this study was to assess the correlation between EEG cortical sources, cerebrospinal fluid (CSF) biomarkers, and neurocognitive tests in PLWH with HAND. PLWH with HAND without significant comorbidities were enrolled. Baseline rsEEG-LORETA waves, CSF biomarkers (t-tau, p-tau, β-amiloid
Identifiants
pubmed: 35044644
doi: 10.1007/s13365-021-01047-y
pii: 10.1007/s13365-021-01047-y
doi:
Substances chimiques
Biomarkers
0
Neopterin
670-65-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
226-235Informations de copyright
© 2022. Journal of NeuroVirology, Inc.
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