Immunologic and Infectious Concerns in Uterus Transplantation.
Journal
Clinical obstetrics and gynecology
ISSN: 1532-5520
Titre abrégé: Clin Obstet Gynecol
Pays: United States
ID NLM: 0070014
Informations de publication
Date de publication:
01 03 2022
01 03 2022
Historique:
entrez:
19
1
2022
pubmed:
20
1
2022
medline:
7
5
2022
Statut:
ppublish
Résumé
Pharmacologic immunosuppression is required for the success of uterus transplantation but can provoke several complications for the transplant recipient. In this review, we discuss the immunologic complications that can occur in the uterus transplant recipient. First, we provide the latest update on immunosuppression regimens used by programs throughout the world. Next, we discuss the prevalence, mechanisms, treatment, and outcome of rejection in uterus transplant recipients. Finally, we discuss infectious complications of varying severity alongside their treatment and impact.
Identifiants
pubmed: 35045023
doi: 10.1097/GRF.0000000000000686
pii: 00003081-202203000-00006
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-43Informations de copyright
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
Références
Brännström M, Johannesson L, Bokström H, et al. Livebirth after uterus transplantation. Lancet. 2015;385:607–616.
Jones BP, Saso S, Bracewell-Milnes T, et al. Human uterine transplantation: a review of outcomes from the first 45 cases. BJOG. 2019;126:1310–1319.
Testa G, McKenna GJ, Bayer J, et al. The evolution of transplantation from saving lives to fertility treatment: DUETS (Dallas UtErus Transplant Study). Ann Surg. 2020;272:411–417.
Flyckt R, Falcone T, Quintini C, et al. First birth from a deceased donor uterus in the United States: from severe graft rejection to successful cesarean delivery. Am J Obstet Gynecol. 2020;223:143–151.
Brännström M, Dahm-Kähler P, Ekberg J, et al. Outcome of recipient surgery and 6-month follow-up of the Swedish Live Donor Robotic Uterus Transplantation Trial. J Clin Med. 2020;9:2338.
Fronek J, Kristek J, Chlupac J, et al. human uterus transplantation from living and deceased donors: the interim results of the first 10 cases of the Czech Trial. J Clin Med. 2021;10:586.
Brucker SY, Strowitzki T, Taran FA, et al. Living-donor uterus transplantation: pre-, intra-, and postoperative parameters relevant to surgical success, pregnancy, and obstetrics with live births. J Clin Med. 2020;9:2485.
Huang Y, Ding X, Chen B, et al. Report of the first live birth after uterus transplantation in People’s Republic of China. Fertil Steril. 2020;114:1108–1115.
Ejzenberg D, Andraus W, Baratelli Carelli Mendes LR, et al. Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility. Lancet. 2019;392:2697–2704.
Deshpande NA, James NT, Kucirka LM, et al. Pregnancy outcomes in kidney transplant recipients: a systematic review and meta-analysis. Am J Transplant. 2011;11:2388–2404.
Boulay H, Mazaud-Guittot S, Supervielle J, et al. Maternal, foetal and child consequences of immunosuppressive drugs during pregnancy in women with organ transplant: a review. Clin Kidney J. 2021;14:1871–1878.
Punnoose LR, Coscia LA, Armenti DP, et al. Pregnancy outcomes in heart transplant recipients. J Heart Lung Transplant. 2020;39:473–480.
Sarkar M, Sawinski D, Coscia L, et al. Pregnancy in liver transplantation. Liver Transpl. 2020;26:954–955.
Zullo F, Saccone G, Donnarumma L, et al. Pregnancy after liver transplantation: a case series and review of the literature. J Matern Fetal Neonatal Med. 2021;34:3269–3276.
Perez-Aytes A, Ledo A, Boso V, et al. In utero exposure to mycophenolate mofetil: a characteristic phenotype? Am J Med Genet A. 2008;146A:1–7.
Erlebacher A. Immunology of the maternal-fetal interface. Annu Rev Immunol. 2013;31:387–411.
Porrett PM. Navigating the murky waters of maternal fetal tolerance: put big data at the helm. Hum Immunol. 2021;82:340–345.
Mölne J, Broecker V, Ekberg J, et al. Monitoring of human uterus transplantation with cervical biopsies: a provisional scoring system for rejection. Am J Transplant. 2017;17:1628–1636.
Agarwal A, Johannesson L, Findeis SK, et al. Clinicopathologic analysis of uterine allografts including proposed scoring of ischemia-reperfusion injury and T cell-mediated rejection-Dallas UtErus transplant study: a pilot study. Transplantation. 2021. doi: 10.1097/TP.0000000000003633
doi: 10.1097/TP.0000000000003633
Puntambekar S, Telang M, Kulkarni P, et al. Laparoscopic-assisted uterus retrieval from live organ donors for uterine transplant: our experience of two patients. J Minim Invasive Gynecol. 2018;25:622–631.
Vento-Tormo R, Efremova M, Botting RA, et al. Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 2018;563:347–353.
Parasar P, Guru N, Nayak NR. Contribution of macrophages to fetomaternal immunological tolerance. Hum Immunol. 2021;82:325–331.
Kisu I, Emoto K, Masugi Y, et al. Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques. Sci Rep. 2020;10:13910.
Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med. 2007;357:2601–2614.
Flyckt R, Davis A, Farrell R, et al. Uterine transplantation: surgical innovation in the treatment of uterine factor infertility. J Obstet Gynaecol Can. 2018;40:86–93.
Brännström M, Johannesson L, Dahm-Kähler P, et al. First clinical uterus transplantation trial: a six-month report. Fertil Steril. 2014;101:1228–1236.
Kisu I, Ishigaki H, Emoto K, et al. Long-term outcome and rejection after allogeneic uterus transplantation in Cynomolgus macaques . J Clin Med. 2020;8:1572.
Britt WJ. Human cytomegalovirus infection in women with preexisting immunity: sources of infection and mechanisms of infection in the presence of antiviral immunity. J Infect Dis. 2020;221(suppl 1):S1–S8.
Rosenzweig M, Wall A, Spak CW, et al. Pregnancy after CMV infection following uterus transplantation: a case report from the Dallas Uterus Transplant Study. Transpl Infect Dis. 2021;23:e13653.
Jing Y, Run-Qian L, Hao-Ran W, et al. Potential influence of COVID-19/ACE2 on the female reproductive system. Mol Hum Reprod. 2020;26:367–373.
Boyarsky BJ, Werbel WA, Avery RK, et al. Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients. JAMA. 2021;325:2204–2206.
Allotey J, Stallings E, Bonet M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020;370:m3320.