Parallel processing of sensory cue and spatial information in the dentate gyrus.
cue cells
dentate gyrus
granule cells
spatial navigation
two-photon imaging
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
18 01 2022
18 01 2022
Historique:
received:
16
08
2021
revised:
28
10
2021
accepted:
21
12
2021
entrez:
19
1
2022
pubmed:
20
1
2022
medline:
15
2
2022
Statut:
ppublish
Résumé
During exploration, animals form an internal map of an environment by combining information about landmarks and the animal's movement, a process that depends on the hippocampus. The dentate gyrus (DG) is the first stage of the hippocampal circuit where self-motion ("where") and sensory cue information ("what") are integrated, but it remains unknown how DG neurons encode this information during cognitive map formation. Using two-photon calcium imaging in mice running on a treadmill along with online cue manipulation, we identify robust sensory cue responses in DG granule cells. Cue cell responses are stable, stimulus-specific, and accompanied by inhibition of nearby neurons. This demonstrates the existence of "cue cells" in addition to better characterized "place cells" in the DG. We hypothesize that the DG supports parallel channels of spatial and non-spatial information that contribute distinctly to downstream computations and affect roles of the DG in spatial navigation and episodic memory.
Identifiants
pubmed: 35045280
pii: S2211-1247(21)01769-1
doi: 10.1016/j.celrep.2021.110257
pmc: PMC8918037
mid: NIHMS1772881
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
110257Subventions
Organisme : NIMH NIH HHS
ID : R01 MH100631
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS094668
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG043688
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH068542
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS104590
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH122965
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH068542
Pays : United States
Organisme : NIH HHS
ID : S10 OD018464
Pays : United States
Organisme : NIMH NIH HHS
ID : K99 MH122226
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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