ISM1 protects lung homeostasis via cell-surface GRP78-mediated alveolar macrophage apoptosis.
Alveolar Epithelial Cells
/ metabolism
Animals
Apoptosis
/ immunology
Bronchoalveolar Lavage Fluid
/ immunology
Disease Models, Animal
Endoplasmic Reticulum Chaperone BiP
/ metabolism
Female
Homeostasis
Inflammation
Intercellular Signaling Peptides and Proteins
/ metabolism
Lung
/ metabolism
Macrophages, Alveolar
/ immunology
Male
Mice
Mice, Inbred BALB C
Phagocytosis
/ physiology
Pulmonary Disease, Chronic Obstructive
/ metabolism
Pulmonary Emphysema
/ metabolism
Smoke
/ adverse effects
Smoking
/ adverse effects
Nicotiana
/ adverse effects
ISM1
alveolar macrophages
apoptosis
cell surface GRP78
chronic obstructive pulmonary disease
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
25 01 2022
25 01 2022
Historique:
accepted:
20
11
2021
entrez:
20
1
2022
pubmed:
21
1
2022
medline:
1
3
2022
Statut:
ppublish
Résumé
Alveolar macrophages (AMs) are critical for lung immune defense and homeostasis. They are orchestrators of chronic obstructive pulmonary disease (COPD), with their number significantly increased and functions altered in COPD. However, it is unclear how AM number and function are controlled in a healthy lung and if changes in AMs without environmental assault are sufficient to trigger lung inflammation and COPD. We report here that absence of isthmin 1 (ISM1) in mice (
Identifiants
pubmed: 35046017
pii: 2019161119
doi: 10.1073/pnas.2019161119
pmc: PMC8794848
pii:
doi:
Substances chimiques
Endoplasmic Reticulum Chaperone BiP
0
Hspa5 protein, mouse
0
Intercellular Signaling Peptides and Proteins
0
Smoke
0
isthmin protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2022 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: R.G. is the scientific founder of NovoBreeze Therapeutics Co. Ltd, a private biopharma company.
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