Loss of Ribosomal Protein Paralog Rpl22-like1 Blocks Lymphoid Development without Affecting Protein Synthesis.
Animals
B-Lymphocytes
/ immunology
Cell Differentiation
/ genetics
Cell Lineage
/ genetics
Cell Plasticity
/ genetics
Gene Expression Profiling
Hematopoietic Stem Cells
/ cytology
Immunophenotyping
Lymphocytes
/ immunology
Lymphopoiesis
/ genetics
Mice
Mice, Knockout
Protein Biosynthesis
Ribosomal Proteins
/ deficiency
Spleen
/ cytology
Tumor Suppressor Protein p53
/ genetics
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
15 02 2022
15 02 2022
Historique:
received:
06
07
2021
accepted:
30
11
2021
pubmed:
21
1
2022
medline:
22
2
2022
entrez:
20
1
2022
Statut:
ppublish
Résumé
Ribosomal proteins are thought to primarily facilitate biogenesis of the ribosome and its ability to synthesize protein. However, in this study, we show that Rpl22-like1 (Rpl22l1) regulates hematopoiesis without affecting ribosome biogenesis or bulk protein synthesis. Conditional loss of murine Rpl22l1 using stage or lineage-restricted Cre drivers impairs development of several hematopoietic lineages. Specifically, Tie2-Cre-mediated ablation of Rpl22l1 in hemogenic endothelium impairs the emergence of embryonic hematopoietic stem cells. Ablation of Rpl22l1 in late fetal liver progenitors impairs the development of B lineage progenitors at the pre-B stage and development of T cells at the CD44
Identifiants
pubmed: 35046107
pii: jimmunol.2100668
doi: 10.4049/jimmunol.2100668
pmc: PMC8827804
mid: NIHMS1762258
doi:
Substances chimiques
RPL22L1 protein, mouse
0
Ribosomal Proteins
0
Tumor Suppressor Protein p53
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
870-880Subventions
Organisme : NIAID NIH HHS
ID : P01 AI102853
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006927
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI110985
Pays : United States
Informations de copyright
Copyright © 2022 by The American Association of Immunologists, Inc.
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