KIFC1 Regulates the Trajectory of Neuronal Migration.
HSET
KIFC1
cytoplasmic dynein
microtubule
molecular motor
neuronal migration
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
16 03 2022
16 03 2022
Historique:
received:
20
08
2021
revised:
03
01
2022
accepted:
10
01
2022
pubmed:
21
1
2022
medline:
22
4
2022
entrez:
20
1
2022
Statut:
ppublish
Résumé
During neuronal migration, forces generated by cytoplasmic dynein yank on microtubules extending from the centrosome into the leading process and move the nucleus along microtubules that extend behind the centrosome. Scaffolds, such as radial glia, guide neuronal migration outward from the ventricles, but little is known about the internal machinery that ensures that the soma migrates along its proper path rather than moving backward or off the path. Here we report that depletion of KIFC1, a minus-end-directed kinesin called HSET in humans, causes neurons to migrate off their appropriate path, suggesting that this molecular motor is what ensures fidelity of the trajectory of migration. For these studies, we used rat migratory neurons
Identifiants
pubmed: 35046122
pii: JNEUROSCI.1708-21.2022
doi: 10.1523/JNEUROSCI.1708-21.2022
pmc: PMC8936618
doi:
Substances chimiques
Kifc1 protein, rat
0
beta Karyopherins
0
Cytoplasmic Dyneins
EC 3.6.4.2
Kinesins
EC 3.6.4.4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2149-2165Subventions
Organisme : NICHD NIH HHS
ID : F31 HD103405
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096098
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS118117
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS028785
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG068597
Pays : United States
Informations de copyright
Copyright © 2022 the authors.
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