Low-Dose Baclofen-Induced Encephalopathy in a Healthy Young Adult: Is Baclofen Toxicity Dose-Dependent?
baclofen toxicity
drug interaction
encephalopathy
nsaids
renal impairment
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
accepted:
17
12
2021
entrez:
20
1
2022
pubmed:
21
1
2022
medline:
21
1
2022
Statut:
epublish
Résumé
Baclofen is a commonly used medication for managing muscle spasticity with the potential of causing life-threatening adverse effects, including encephalopathy as well as withdrawal symptoms including confusion and hallucinations following abrupt discontinuation. Severe toxicity with baclofen is common in patients with kidney disease, hence the importance of dose reduction and monitoring in patients with renal impairment. This article reports a case of encephalopathy with low-dose baclofen in an otherwise healthy young adult concurrently taking ibuprofen and baclofen and aims to underscore the importance of potential drug interaction and patient education when initiating baclofen.
Identifiants
pubmed: 35047311
doi: 10.7759/cureus.20499
pmc: PMC8760001
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e20499Informations de copyright
Copyright © 2021, Ibeson et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Kidney Dis. 2018 Feb;71(2):275-280
pubmed: 28899601
Am J Case Rep. 2015 Apr 20;16:232-5
pubmed: 25895118
J Clin Neurophysiol. 2019 May;36(3):209-212
pubmed: 30688773
Arch Neurol. 1988 Jul;45(7):814-5
pubmed: 3390037
Ann Pharmacother. 2006 Nov;40(11):2071-3
pubmed: 17047139
Drug Intell Clin Pharm. 1984 Oct;18(10):805-8
pubmed: 6489161
Ann Neurol. 1985 Jun;17(6):617-8
pubmed: 4026235
SAGE Open Med. 2021 Jun 3;9:20503121211022197
pubmed: 34158937
World Neurosurg. 2020 Apr;136:136-139
pubmed: 31954899
Ther Adv Drug Saf. 2017 May;8(5):165-167
pubmed: 28588762
Ital J Neurol Sci. 1991 Jun;12(3):323-5
pubmed: 1874611
Postgrad Med J. 2020 Dec;96(1142):780-781
pubmed: 32114492
Emerg Med Australas. 2006 Feb;18(1):77-82
pubmed: 16454779