Variation in taste ganglion neuron morphology: insights into taste function and plasticity.
Journal
Current opinion in physiology
ISSN: 2468-8673
Titre abrégé: Curr Opin Physiol
Pays: England
ID NLM: 101715200
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
entrez:
20
1
2022
pubmed:
21
1
2022
medline:
21
1
2022
Statut:
ppublish
Résumé
Chemical information from food is transduced by cells in the taste bud (taste-transducing cells) and carried to the brain by peripheral taste ganglion neurons. These neurons are thought to act simply as cables without any transformation of the signal or circuitry between the taste-transducing cells and the neurons. However, these neurons vary in structure, particularly in the extent of their peripheral axon branching. Such structural differences would be expected to underlie differences in the number of taste-transducing cells providing convergent information to these neurons. However, axon branching may vary over time and morphological differences between neurons might also reflect neuron plasticity. Because taste-transducing cells die and are replaced, the morphology of neurons may change as they form connections with new cells within the taste bud. Modern genetic approaches may permit investigations of the complex relationship among gustatory neuron morphology, circuitry, and function. This review discusses potential relationships among peripheral taste neuron morphology, function, and plasticity to help advance our understanding of taste system function and dysfunction.
Identifiants
pubmed: 35047711
doi: 10.1016/j.cophys.2020.12.011
pmc: PMC8765802
mid: NIHMS1769725
doi:
Types de publication
Journal Article
Langues
eng
Pagination
134-139Subventions
Organisme : NIDCD NIH HHS
ID : F31 DC017660
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC007176
Pays : United States
Organisme : NIDCD NIH HHS
ID : R21 DC014857
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interest statement Nothing declared.
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