A whole-exome case-control association study to characterize the contribution of rare coding variation to pancreatic cancer risk.
ATM
Association Analysis
Case-Control Study
Pancreatic Cancer
SIK3
Journal
HGG advances
ISSN: 2666-2477
Titre abrégé: HGG Adv
Pays: United States
ID NLM: 101772885
Informations de publication
Date de publication:
13 Jan 2022
13 Jan 2022
Historique:
received:
13
07
2021
accepted:
08
12
2021
entrez:
20
1
2022
pubmed:
21
1
2022
medline:
21
1
2022
Statut:
epublish
Résumé
Pancreatic cancer is a deadly disease that accounts for approximately 5% of cancer deaths worldwide, with a dismal 5-year survival rate of 10%. Known genetic risk factors explain only a modest proportion of the heritable risk of pancreatic cancer. We conducted a whole-exome case-control sequencing study in 1,591 pancreatic cancer cases and 2,134 cancer-free controls of European ancestry. In our gene-based analysis,
Identifiants
pubmed: 35047863
doi: 10.1016/j.xhgg.2021.100078
pii: S2666-2477(21)00059-2
pmc: PMC8756505
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100078Subventions
Organisme : NCI NIH HHS
ID : R01 CA177935
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA188943
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM133169
Pays : United States
Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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