Agricultural exposure and risk of soft tissue sarcomas and gastrointestinal stromal sarcoma in the AGRIculture and CANcer (AGRICAN) cohort.


Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
01 06 2022
Historique:
revised: 22 12 2021
received: 25 03 2021
accepted: 04 01 2022
pubmed: 21 1 2022
medline: 6 4 2022
entrez: 20 1 2022
Statut: ppublish

Résumé

Sarcomas are a heterogeneous group of tumors whose incidence is nearly 5 per 100 000 inhabitants in Europe. Their causes are poorly understood, although occupational exposures (especially farming and pesticides) are suspected. The AGRICAN cohort is a prospective study of 181 842 individuals enrolled in 2005 to 2007 who completed an enrolment questionnaire with data on lifelong agricultural exposure. Associations between agricultural exposure and sarcoma overall, gastrointestinal stromal tumors (GIST) and myomatous and fibrous sarcoma together, were analyzed with a Cox model. Until 2015, 188 incident cases of sarcoma were identified. Increased risks were observed (a) among cattle farmers working <10 years (HR

Identifiants

pubmed: 35048371
doi: 10.1002/ijc.33936
doi:

Substances chimiques

Pesticides 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1792-1803

Informations de copyright

© 2022 UICC.

Références

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Auteurs

Marine Renier (M)

INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.
UFR de Santé, Université de Caen Normandie, Caen, France.

Amandine Busson (A)

INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.
UFR de Santé, Université de Caen Normandie, Caen, France.

Mathilde Boulanger (M)

INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.
UFR de Santé, Université de Caen Normandie, Caen, France.
Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France.

Clément Piel (C)

INSERM, Bordeaux Population Health Research Center, Team EPICENE, Université de Bordeaux, Bordeaux, France.

Romain Pons (R)

INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.
UFR de Santé, Université de Caen Normandie, Caen, France.
Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France.

Séverine Tual (S)

INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.
UFR de Santé, Université de Caen Normandie, Caen, France.
Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France.

Brice Amadéo (B)

INSERM, Bordeaux Population Health Research Center, Team EPICENE, Université de Bordeaux, Bordeaux, France.
FRANCIM, Réseau National du Registre des Cancers, Toulouse, France.

Matthieu Meryet-Figuiere (M)

INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.
UFR de Santé, Université de Caen Normandie, Caen, France.
Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France.

Elisabeth Marcotullio (E)

Caisse Centrale de la Mutualité Sociale Agricole, Echelon National Santé Sécurité au Travail, Bagnolet, France.

Bénédicte Clin (B)

INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.
UFR de Santé, Université de Caen Normandie, Caen, France.
Occupational Health Department, CHU de Caen, Caen, France.

Isabelle Baldi (I)

INSERM, Bordeaux Population Health Research Center, Team EPICENE, Université de Bordeaux, Bordeaux, France.
Public Health Unit, Occupational Medicine and Pathology Department, CHU de Bordeaux, Bordeaux, France.

Pierre Lebailly (P)

INSERM, UMR 1086 ANTICIPE Cancers & Préventions, Caen, France.
UFR de Santé, Université de Caen Normandie, Caen, France.
Cancers & Préventions, Centre de Lutte Contre le Cancer François Baclesse, Caen, France.

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