Clozapine-Encapsulated Binary Mixed Micelles in Thermosensitive Sol-Gels for Intranasal Administration.
antipsychotic
cardiomyopathy
clozapine
constipation
hydrogel
hypersalivation
metabolic syndrome
nose-to-brain delivery
poloxamer gel
polysorbates
postural hypotension
schizophrenia
Journal
Gels (Basel, Switzerland)
ISSN: 2310-2861
Titre abrégé: Gels
Pays: Switzerland
ID NLM: 101696925
Informations de publication
Date de publication:
05 Jan 2022
05 Jan 2022
Historique:
received:
14
12
2021
revised:
02
01
2022
accepted:
03
01
2022
entrez:
20
1
2022
pubmed:
21
1
2022
medline:
21
1
2022
Statut:
epublish
Résumé
(1) Background: Clozapine is the most effective antipsychotic. It is, however, associated with many adverse drug reactions. Nose-to-brain (N2B) delivery offers a promising approach. This study aims to develop clozapine-encapsulated thermosensitive sol-gels for N2B delivery. (2) Methods: Poloxamer 407 and hydroxypropyl methylcellulose were mixed and hydrated with water. Glycerin and carbopol solutions were added to the mixture and stirred overnight at 2-8 °C. Clozapine 0.1%
Identifiants
pubmed: 35049572
pii: gels8010038
doi: 10.3390/gels8010038
pmc: PMC8774880
pii:
doi:
Types de publication
Journal Article
Langues
eng
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