Antimicrobial, Insecticidal and Cytotoxic Activity of Linear Venom Peptides from the Pseudoscorpion
antimicrobial activity
antimicrobial peptides
checacin
cytotoxic activity
insecticidal activity
megicin
pseudoscorpion venom
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
14 01 2022
14 01 2022
Historique:
received:
30
11
2021
revised:
27
12
2021
accepted:
04
01
2022
entrez:
20
1
2022
pubmed:
21
1
2022
medline:
3
3
2022
Statut:
epublish
Résumé
Linear cationic venom peptides are antimicrobial peptides (AMPs) that exert their effects by damaging cell membranes. These peptides can be highly specific, and for some, a significant therapeutic value was proposed, in particular for treatment of bacterial infections. A prolific source of novel AMPs are arthropod venoms, especially those of hitherto neglected groups such as pseudoscorpions. In this study, we describe for the first time pharmacological effects of AMPs discovered in pseudoscorpion venom. We examined the antimicrobial, cytotoxic, and insecticidal activity of full-length Checacin1, a major component of the
Identifiants
pubmed: 35051034
pii: toxins14010058
doi: 10.3390/toxins14010058
pmc: PMC8778599
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Arthropod Proteins
0
Arthropod Venoms
0
Cytotoxins
0
Insecticides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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